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Blood, 15 July 2005, Vol. 106, No. 2, pp. 740-745. Prepublished online as a Blood First Edition Paper on March 24, 2005; DOI 10.1182/blood-2005-02-0713. This Article Full Text (PDF) All Versions of this Article: 2005-02-0713v1 106/2/740    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Beutler, E. Articles by West, C. Search for Related Content PubMed PubMed Citation Articles by Beutler, E. Articles by West, C. Related Collections Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 22, 2005 Accepted March 16, 2005 Hematologic differences between African-Americans and whites: the roles of iron deficiency and -thalassemia on hemoglobin levels and MCV Ernest Beutler* and Carol West Department of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA * Corresponding author; email: beutler{at}scripps.edu. The average results of some laboratory measurements, including the hemoglobin, mean corpuscular volume, serum transferrin saturation (TS), serum ferritin, and white count of African-Americans differ from those of Whites. Anonymized samples and laboratory data from 1,491 African-American and 31,005 White subjects, approximately equally divided between men and women, were analyzed. The hematocrit, hemoglobin, MCV, and transferrin saturation, and white blood counts of African-Americans were lower than those of Whites; transferrin saturations were higher. When iron deficient patients were eliminated from consideration the differences in hematocrit, hemoglobin, and MCV among women were slightly less. The -3.7kb -thalassemia deletion accounted for about one-third of the difference in the hemoglobin levels of African-Americans and Whites and neither sickle trait nor elevated creatinine levels had an effect. Among all subjects 19.8% of African-American females would have been classified as 'anemic' compared to 5.3% of Whites. Among males the figures were 17.7% and 7.6%. Without iron deficient or thalassemic subjects, the difference had narrowed to 6.1% and 2.77% and to 4.29% and 3.6% respectively. Physicians need to take into account that the same reference standards for hemoglobin, hematocrit, MCV, and TS and the white blood count do not apply to all ethnic groups. 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