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Blood, 15 October 2005, Vol. 106, No. 8, pp. 2879-2883.
Prepublished online as a Blood First Edition Paper on June 16, 2005; DOI 10.1182/blood-2005-02-0716.
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Submitted February 22, 2005
Accepted June 6, 2005
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
Hiromi Gunshin, Carolyn N Starr, Cristina DiRenzo, Mark D Fleming, Jie Jin, Eric L Greer, Vera M Sellers, Stephanie M Galica, and Nancy C Andrews*
Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Boston, MA, USA
Howard Hughes Medical Institute, Boston, MA, USA
* Corresponding author; email: nandrews{at}enders.tch.harvard.edu.
Mammalian non-heme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine. This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells. To test its importance in vivo, we inactivated the murine Cybrd1 gene and assessed tissue iron stores in Cybrd1 null mice. We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron.
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