|
|
Blood, 1 September 2005, Vol. 106, No. 5, pp. 1519-1524.
Prepublished online as a Blood First Edition Paper on May 24, 2005; DOI 10.1182/blood-2005-02-0717.
 Previous Article | Next Article 
Submitted February 23, 2005
Accepted May 2, 2005
Effect of transcription factor concentrations on leukemic stem cells
Frank Rosenbauer, Steffen Koschmieder, Ulrich Steidl, and Daniel G Tenen*
Harvard Institutes of Medicine, Harvard Medical School, Boston, MA, USA
* Corresponding author; email: dtenen{at}bidmc.harvard.edu.
Increasing evidence suggests that leukemias are sustained by leukemic stem cells. However, the molecular pathways underlying the transformation of normal cells into leukemic stem cells are still poorly understood. The involvement of a small group of key transcription factors into this process was suggested by their frequent mutation or downregulation in individuals with acute myeloid leukemia (AML). However, knockout mice harboring complete disruption of transcription factor genes did not provide definitive proof of their role in this malignant disease. Recent findings in mice suggest that leukemic stem cell formation in AML might require residual transcription factor function, and is therefore associated with graded reduction rather than complete loss. In support of this novel concept is the paucity of bi-allelic null-mutations or deletions in transcription factor genes in human AML. Here, we discuss the effects of transcription factor concentrations on hematopoiesis and leukemia, with a focus on the regulation of transcription factor gene expression as a major mechanism that alters critical threshold levels during blood development and cancer.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
A. Schuler, M. Schwieger, A. Engelmann, K. Weber, S. Horn, U. Muller, M. A. Arnold, E. N. Olson, and C. Stocking
The MADS transcription factor Mef2c is a pivotal modulator of myeloid cell fate
Blood,
May 1, 2008;
111(9):
4532 - 4541.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Carradice and G. J. Lieschke
Zebrafish in hematology: sushi or science?
Blood,
April 1, 2008;
111(7):
3331 - 3342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Bruns, U. Steidl, J. C. Fischer, A. Czibere, G. Kobbe, S. Raschke, R. Singh, R. Fenk, M. Rosskopf, S. Pechtel, et al.
Pegylated granulocyte colony-stimulating factor mobilizes CD34+ cells with different stem and progenitor subsets and distinct functional properties in comparison with unconjugated granulocyte colony-stimulating factor
Haematologica,
March 1, 2008;
93(3):
347 - 355.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-R. J. Yeh, K. M. Munson, Y. L. Chao, Q. P. Peterson, C. A. MacRae, and R. T. Peterson
AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression
Development,
January 15, 2008;
135(2):
401 - 410.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Rosa, M. Ballarino, A. Sorrentino, O. Sthandier, F. G. De Angelis, M. Marchioni, B. Masella, A. Guarini, A. Fatica, C. Peschle, et al.
The interplay between the master transcription factor PU.1 and miR-424 regulates human monocyte/macrophage differentiation
PNAS,
December 11, 2007;
104(50):
19849 - 19854.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Frontelo, D. Manwani, M. Galdass, H. Karsunky, F. Lohmann, P. G. Gallagher, and J. J. Bieker
Novel role for EKLF in megakaryocyte lineage commitment
Blood,
December 1, 2007;
110(12):
3871 - 3880.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Koschmieder, F. D'Alo, H. Radomska, C. Schoneich, J. S. Chang, M. Konopleva, S. Kobayashi, E. Levantini, N. Suh, A. Di Ruscio, et al.
CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha
Blood,
November 15, 2007;
110(10):
3695 - 3705.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Redell, A. Tsimelzon, S. G. Hilsenbeck, and D. J. Tweardy
Conditional overexpression of Stat3{alpha} in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern
J. Leukoc. Biol.,
October 1, 2007;
82(4):
975 - 985.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Rodenburg, M. Fischer, A. Engelmann, S. O. Harbers, M. Ziegler, J. Lohler, and C. Stocking
Importance of Receptor Usage, Fli1 Activation, and Mouse Strain for the Stem Cell Specificity of 10A1 Murine Leukemia Virus Leukemogenicity
J. Virol.,
January 15, 2007;
81(2):
732 - 742.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Chapiro, L. Russell, I. Radford-Weiss, C. Bastard, M. Lessard, S. Struski, H. Cave, S. Fert-Ferrer, C. Barin, O. Maarek, et al.
Overexpression of CEBPA resulting from the translocation t(14;19)(q32;q13) of human precursor B acute lymphoblastic leukemia
Blood,
November 15, 2006;
108(10):
3560 - 3563.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Zhou, K. M. Pawlik, J. Ren, C.-W. Sun, and T. M. Townes
Differential Binding of Erythroid Krupple-like Factor to Embryonic/Fetal Globin Gene Promoters during Development
J. Biol. Chem.,
June 9, 2006;
281(23):
16052 - 16057.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Metcalf, A. Dakic, S. Mifsud, L. Di Rago, L. Wu, and S. Nutt
Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
PNAS,
January 31, 2006;
103(5):
1486 - 1491.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
