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Blood, 15 September 2005, Vol. 106, No. 6, pp. 2156-2161. Prepublished online as a Blood First Edition Paper on May 26, 2005; DOI 10.1182/blood-2005-02-0761. This Article Full Text (PDF) All Versions of this Article: 2005-02-0761v1 106/6/2156    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chng, W. J Articles by Fonseca, R. Search for Related Content PubMed PubMed Citation Articles by Chng, W. J Articles by Fonseca, R. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 23, 2005 Accepted May 16, 2005 A validated FISH trisomy index demonstrates the hyperdiploid and non-hyperdiploid dichotomy in MGUS Wee J Chng*, Scott A Van Wier, Gregory J Ahmann, Jerry M Winkler, Syed M Jalal, P L Bergsagel, Marta Chesi, Mike C Trendle, Martin M Oken, Emily Blood, Kim Henderson, Rafael Santana-Davila, Robert A Kyle, Morie A Gertz, Martha Q Lacy, Angela Dispenzieri, Philip R Greipp, and Rafael Fonseca Comprehensive Cancer Center and Division of Hematology and Oncology, Mayo Clinic Scottsdale, Scottsdale, AZ, USA Division of Hematology, Mayo Clinic Rochester, Rochester, MN, USA Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Rochester, MN, USA Missouri Cancer Associates, Missouri, USA North Memorial Cancer Center, Robbinsdale, MN, USA Eastern Cooperative Oncology Group (ECOG) Statistical Center, Dana Farber Cancer Institute, Boston, MA, USA * Corresponding author; email: chngwj{at}nuh.com.sg. Two major genetic categories of multiple myeloma (MM) exist. Hyperdiploid MM (48 to 74 chromosomes, median 53 chromosomes) is associated with trisomies especially of chromosomes 3,7,9,11,15, and 19 while the non-hyperdiploid (less than 48 chromosomes or more than 74 chromosomes) MM is associated with primary translocations such as t(11;14), t(4;14) and t(14;16). Whether this dichotomy exist in MGUS is uncertain due to limitations of current methods in the study of ploidy. This is especially true in MGUS where the number of clonal plasma cells is small. In this study, we derived a FISH based trisomy index from pooled cytogenetic data (karyotype analysis) from 2 large cohorts of MM patients with abnormal karyotype and then validate it in 2 independent cohorts of patients who had known ploidy status either by karyotyping or DNA content measurement using flow cytometry. Using the criteria of 2 or more trisomies from a 3-chromosome combination, hyperdiploid myeloma can be detected with high specificity. Applying this index on 28 SMM/MGUS (11 SMM and 17 MGUS) patients who had normal karyotype, 11 hyperdiploid SMM/MGUS were detected. This percentage (40%) is remarkably similar to the percentage of hyperdiploid MM reported in the literature, suggesting that hyperdiploid MM may originate early during disease evolution. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: O. Landgren, L. R. Goldin, N. E. Caporaso, R. A. Kyle, and S. V. Rajkumar Genetic Predisposition for Monoclonal Gammopathy of Undetermined Significance-reply-I Mayo Clin. Proc., May 1, 2008; 83(5): 602 - 603. [Full Text] [PDF] T. Bochtler, U. Hegenbart, F. W. Cremer, C. Heiss, A. Benner, D. Hose, M. Moos, J. Bila, C. R. Bartram, A. D. Ho, et al. Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability Blood, May 1, 2008; 111(9): 4700 - 4705. [Abstract] [Full Text] [PDF] K. Bink, E. Haralambieva, M. Kremer, G. Ott, C. Beham-Schmid, L. de Leval, S. C. Peh, H. R. Laeng, U. Jutting, P. Hutzler, et al. Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics Haematologica, April 1, 2008; 93(4): 623 - 626. [Abstract] [Full Text] [PDF] M. Brousseau, X. Leleu, J. Gerard, T. Gastinne, A. Godon, F. Genevieve, M. Dib, J.-L. Lai, T. Facon, M. Zandecki, et al. Hyperdiploidy Is a Common Finding in Monoclonal Gammopathy of Undetermined Significance and Monosomy 13 Is Restricted to These Hyperdiploid Patients Clin. Cancer Res., October 15, 2007; 13(20): 6026 - 6031. [Abstract] [Full Text] [PDF] W. J. Chng, S. Kumar, S. VanWier, G. Ahmann, T. Price-Troska, K. Henderson, T.-H. Chung, S. Kim, G. Mulligan, B. Bryant, et al. Molecular Dissection of Hyperdiploid Multiple Myeloma by Gene Expression Profiling Cancer Res., April 1, 2007; 67(7): 2982 - 2989. [Abstract] [Full Text] [PDF] F. Zhan, B. Barlogie, V. Arzoumanian, Y. Huang, D. R. Williams, K. Hollmig, M. Pineda-Roman, G. Tricot, F. van Rhee, M. Zangari, et al. Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis Blood, February 15, 2007; 109(4): 1692 - 1700. [Abstract] [Full Text] [PDF] L. Agnelli, S. Bicciato, S. Fabris, L. Baldini, F. Morabito, D. Intini, D. Verdelli, A. Callegaro, F. Bertoni, G. Lambertenghi-Deliliers, et al. Integrative genomic analysis reveals distinct transcriptional and genetic features associated with chromosome 13 deletion in multiple myeloma Haematologica, January 1, 2007; 92(1): 56 - 65. [Abstract] [Full Text] [PDF] F. Zhan, Y. Huang, S. Colla, J. P. Stewart, I. 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