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Blood, 15 May 2006, Vol. 107, No. 10, pp. 3907-3911. Prepublished online as a Blood First Edition Paper on January 24, 2006; DOI 10.1182/blood-2005-02-0802. This Article Full Text (PDF) All Versions of this Article: 2005-02-0802v1 107/10/3907    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Robertson, C. Articles by McNicol, A. Search for Related Content PubMed PubMed Citation Articles by Robertson, C. Articles by McNicol, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 28, 2005 Accepted January 13, 2006 Cellular prion protein is released on exosomes from activated platelets Catherine Robertson, Stephanie A Booth, Daniel R Beniac, Michael B Coulthart, Timothy F Booth, and Archibald McNicol* Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada; Division of Host Genetics & Prion Diseases, Canadian Science Centre for Human & Animal Health, Winnipeg, Manitoba, Canada Division of Host Genetics & Prion Diseases, Canadian Science Centre for Human & Animal Health, Winnipeg, Manitoba, Canada; Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada Division of Viral Diseases, Canadian Science Centre for Human & Animal Health, Winnipeg, Manitoba, Canada Department of Medical Microbiology, University of Manitoba, Winnipeg, Manitoba, Canada; Division of Viral Diseases, Canadian Science Centre for Human & Animal Health, Winnipeg, Manitoba, Canada Department of Oral Biology, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada * Corresponding author; email: mcnicol{at}ms.umanitoba.ca. Cellular prion protein (PrPC) is a glycophosphatidylinositol (GPI) anchored protein, of unknown function, found in a number of tissues throughout the body, including several blood components of which platelets constitute the largest reservoir in humans. It is widely believed that a mis-folded, protease-resistant form of PrPC, PrPSc, is responsible for the transmissible spongiform encephalopathy (TSE) group of fatal neurodegenerative diseases. Although the pathogenesis of TSEs is poorly understood, it is known that PrPC must be present in order for the disease to progress, and thus it is important to determine the physiological function of PrPC. Resolving the location of PrPC in blood will provide valuable clues as to its function. PrPC was previously shown to be on the alpha granule membrane of resting platelets. In the current study platelet activation led to the transient expression of PrPC on the platelet surface and its subsequent release on both microvesicles and exosomes. The presence of PrPC on platelet-derived exosomes suggests a possible mechanism for PrPC transport in blood and for cell-to-cell transmission. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Linden, V. R. Martins, M. A. M. Prado, M. Cammarota, I. Izquierdo, and R. R. Brentani Physiology of the Prion Protein Physiol Rev, April 1, 2008; 88(2): 673 - 728. [Abstract] [Full Text] [PDF] W. M. Dlakic, E. Grigg, and R. A. Bessen Prion Infection of Muscle Cells In Vitro J. Virol., May 1, 2007; 81(9): 4615 - 4624. [Abstract] [Full Text] [PDF] G. van Niel, I. Porto-Carreiro, S. Simoes, and G. Raposo Exosomes: a common pathway for a specialized function. J. Biochem., July 1, 2006; 140(1): 13 - 21. [Abstract] [Full Text] [PDF]

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