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Blood, 1 September 2005, Vol. 106, No. 5, pp. 1864-1866. Prepublished online as a Blood First Edition Paper on May 10, 2005; DOI 10.1182/blood-2005-03-1159. This Article Full Text (PDF) All Versions of this Article: 2005-03-1159v1 106/5/1864    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kemna, E. H Articles by Swinkels, D. Search for Related Content PubMed PubMed Citation Articles by Kemna, E. H Articles by Swinkels, D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 22, 2005 Accepted May 2, 2005 Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS Erwin H Kemna*, Peter Pickkers, Elizabeta Nemeth, Hans van der Hoeven, and Dorine Swinkels Department of Clinical Chemistry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA * Corresponding author; email: E.Kemna{at}akc.umcn.nl. Hepatic peptide hormone hepcidin is the key regulator of iron metabolism and the mediator of anemia of inflammation. Previous studies indicated that IL-6 mediates hepcidin increase and consequent hypoferremia during inflammation. Here we used an in vivo human endotoxemia model to analyze the effects of lipopolysaccharide (LPS) as a more upstream inflammation activator. The temporal associations between plasma cytokines, hepcidin levels and serum iron parameters were studied in 10 healthy subjects after LPS injection. IL-6 was dramatically induced within 3 h after injection and urinary hepcidin peaked within 6 h, followed by a significant decrease in serum iron. Serum pro-hepcidin showed no significant change within a 22 h time frame. These in vivo human results confirm the importance of IL-6-hepcidin axis in development of hypoferremia in inflammation and highlight the rapid responsiveness of this iron regulatory system. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. Brendt, A. Horwat, S. T. Schafer, S. C. Dreyer, J. Gothert, and J. 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