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Blood, 1 October 2005, Vol. 106, No. 7, pp. 2491-2497. Prepublished online as a Blood First Edition Paper on June 9, 2005; DOI 10.1182/blood-2005-03-1175. This Article Full Text (PDF) All Versions of this Article: 2005-03-1175v1 106/7/2491    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kodama, K. Articles by Cerroni, L. Search for Related Content PubMed PubMed Citation Articles by Kodama, K. Articles by Cerroni, L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 23, 2005 Accepted May 25, 2005 Primary cutaneous large B-cell lymphomas. Clinicopathologic features, classification, and prognostic factors in a large series of patients. Kazuo Kodama, Cesare Massone, Andreas Chott, Dieter Metze, Helmut Kerl, and Lorenzo Cerroni* Departments of Dermatology, Medical University, Graz, Austria; Hokkaido University, Sapporo, Japan Departments of Dermatology, Medical University, Graz, Austria Department of Pathology, Medical University of Vienna, Vienna, Austria University of Munster, Munster, Germany * Corresponding author; email: lorenzo.cerroni{at}meduni-graz.at. In the new World Health Organization/European Organization for Research and Treatment of Cancer (WHO/EORTC) classification of cutaneous lymphomas, large B-cell lymphomas (LBCLs) are divided into 3 groups: LBCL, leg-type (LBCLLT); follicle center lymphoma, diffuse type (FCLDT); LBCL, others (LBCLO). We studied a large number of primary cutaneous LBCLs in order to test the validity of the classification, and to identify prognostic factors for these patients. Ninety-three cases of primary cutaneous LBCL were analyzed for clinicopathologic features, expression of several markers including Bcl-2, Bcl-6, MUM-1, and FOX-P1, in-situ-hybridization for Epstein-Barr virus, and molecular analyses of IgH gene rearrangement and of Borrelia burgdorferi and Human herpesvirus 8 DNA. Patients were classified into the following categories: FCLDT: 44 cases; LBCLLT: 40 cases. LBCLO: 9 cases. Statistical analyses showed that the groups of LBCLLT and FCLDT were clearly distinct in terms of clinicopathologic features and survival. The group of LBCLO had features in-between those of LBCLLT and FCLDT. Our study shows that accurate morphologic and phenotypic analyses allow to stratify most patients into the prognostically different categories of LBCLLT and FCLDT. The definition of a third category of LBCLO requires further studies to clarify whether these cases show indeed distinct clinicopathologic features. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. J. Brown, S. L. Ashe, E. Leich, C. Burek, S. Barrans, J. A. Fenton, A. S. Jack, K. Pulford, A. Rosenwald, and A. H. Banham Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL Blood, March 1, 2008; 111(5): 2816 - 2824. [Abstract] [Full Text] [PDF] N. J. Senff, J. J. Hoefnagel, K. J. Neelis, M. H. Vermeer, E. M. Noordijk, R. Willemze, and for the Dutch Cutaneous Lymphoma Group Results of Radiotherapy in 153 Primary Cutaneous B-Cell Lymphomas Classified According to the WHO-EORTC Classification Arch Dermatol, December 1, 2007; 143(12): 1520 - 1526. [Abstract] [Full Text] [PDF] F. Grange, M. Beylot-Barry, P. Courville, E. Maubec, M. Bagot, B. Vergier, P. Souteyrand, L. Machet, S. Dalac, E. Esteve, et al. Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: Clinicopathologic Features and Prognostic Analysis in 60 Cases Arch Dermatol, September 1, 2007; 143(9): 1144 - 1150. [Abstract] [Full Text] [PDF] N. J. Senff, J. J. Hoefnagel, P. M. Jansen, M. H. Vermeer, J. van Baarlen, W. A. Blokx, M. R. Canninga-van Dijk, M.-L. Geerts, K. M. Hebeda, P. M. Kluin, et al. Reclassification of 300 Primary Cutaneous B-Cell Lymphomas According to the New WHO-EORTC Classification for Cutaneous Lymphomas: Comparison With Previous Classifications and Identification of Prognostic Markers J. Clin. Oncol., April 20, 2007; 25(12): 1581 - 1587. [Abstract] [Full Text] [PDF] Persistent Violaceous Papules on the Ears--Diagnosis Arch Dermatol, March 1, 2007; 143(3): 417 - 422. [Full Text] [PDF] L Cerroni Lymphoproliferative lesions of the skin. J. Clin. Pathol., August 1, 2006; 59(8): 813 - 826. [Abstract] [Full Text] [PDF]

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