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Blood, 15 September 2005, Vol. 106, No. 6, pp. 1992-1994. Prepublished online as a Blood First Edition Paper on June 14, 2005; DOI 10.1182/blood-2005-03-1247. This Article Full Text (PDF) All Versions of this Article: 2005-03-1247v1 106/6/1992    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pignatelli, P. Articles by Violi, F. Search for Related Content PubMed PubMed Citation Articles by Pignatelli, P. Articles by Violi, F. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 28, 2005 Accepted May 20, 2005 Tumor necrosis factor-alpha as trigger of platelet activation in patients with heart failure Pasquale Pignatelli, Luciano De Biase, Luisa Lenti, Giuliano Tocci, Alessandra Brunelli, Roberto Cangemi, Silvia Riondino, Susanna Grego, Massimo Volpe, and Francesco Violi* Divisione IV Clinica Medica, Policlinico Umberto I, Universita "La Sapienza" di Roma, Rome, Italy Ospedale Sant'Andrea, Cardiologia, II Facolta di Medicina e Chirurgia, Universita "La Sapienza" di Roma, Rome, Italy Dipartimento di Medicina Sperimentale e Patologia, Policlinico Umberto I, Universita "La Sapienza" di Roma, Rome, Italy Dipartimento di Scienze dell'Invecchiamento, Policlinico Umberto I, Universita "La Sapienza" di Roma, Rome, Italy * Corresponding author; email: francesco.violi{at}uniroma1.it. Clinical history of patients with Heart Failure (HF) is complicated by arterial thromboembolism. Platelet activation was reported in this setting, but the underlying mechanism has not been clarified. 42 patients with HF scored according to NYHA classification had higher collagen-induced platelet aggregation, platelet tumor necrosis factor-alpha (TNF-) receptor expression, serum thromboxane B2 and circulating levels of TNF- than 20 healthy subjects. Coincubation of platelets from HF patients with an inhibitor of TNF- receptors significantly reduced collagen induced platelet aggregation. In vitro study demonstrated that TNF- amplified the platelet response to collagen; this effect was inhibited by (a) TNF- receptor antagonist and (b) inhibitors of arachidonic acid metabolism. This study shows that TNF- behaves as a trigger of platelet activation via stimulation of the arachidonic acid pathway. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Y. Wang, Y. Zhou, L. Meng, X. Lu, N. Ou, and X. Li Inflammatory Mediators in Chinese Patients With Congestive Heart Failure J. Clin. Pharmacol., May 1, 2009; 49(5): 591 - 599. [Abstract] [Full Text] [PDF] P. Pignatelli, R. Cangemi, A. Celestini, R. Carnevale, L. Polimeni, A. Martini, D. Ferro, L. Loffredo, and F. Violi Tumour necrosis factor {alpha} upregulates platelet CD40L in patients with heart failure Cardiovasc Res, June 1, 2008; 78(3): 515 - 522. [Abstract] [Full Text] [PDF] L. H. Opie and S. Lecour The red wine hypothesis: from concepts to protective signalling molecules Eur. Heart J., July 2, 2007; 28(14): 1683 - 1693. [Abstract] [Full Text] [PDF]

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