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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1255-1264. Prepublished online as a Blood First Edition Paper on October 6, 2005; DOI 10.1182/blood-2005-03-1306. This Article Full Text (PDF) All Versions of this Article: 2005-03-1306v1 107/4/1255    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rizvi, M. A Articles by Rosen, S. T Search for Related Content PubMed PubMed Citation Articles by Rizvi, M. A Articles by Rosen, S. T Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 30, 2005 Accepted August 16, 2005 T-cell non-Hodgkin's lymphoma Mujahid A Rizvi*, Andrew M Evens, Martin S Tallman, Beverly P Nelson, and Steven T Rosen Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; The Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA Division of Hematopathology, Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA * Corresponding author; email: m-rizvi{at}md.northwestern.edu. T-cell non-Hodgkin's lymphomas (NHL) are uncommon malignancies. The current WHO/EORTC classification recognizes 9 distinct clinico-pathologic peripheral T-cell NHLs. These disorders have unique characteristics and require individualized diagnostic and therapeutic strategies. In recent years there has been tremendous progress in the understanding of the pathogenesis of these disorders. Specific chromosomal translocations and viral infections are now known to be associated with certain lymphomas. In this review, we describe both the clinical and pathologic features. We also discuss the use of molecular studies in the diagnostic work-up of T-cell lymphomas. Due to the rarity of these disorders and the lack of well-designed clinical trials, the treatment of peripheral T-cell NHLs is often challenging. In conclusion, further studies are required to learn more about the biology of these diseases, which may lead to more optimal and possibly targeted therapies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. J. Otero, J. P. Jagannathan, L. M. Prevedello, C. J. Johnston, N. H. Ramaiya, A. D. Van den Abbeele, and P. J. DiPiro CT and PET/CT Findings of T-Cell Lymphoma Am. J. Roentgenol., August 1, 2009; 193(2): 349 - 358. [Abstract] [Full Text] [PDF] A. K. Gopal, J. M. Pagel, J. R. Fromm, S. Wilbur, and O. W. Press 131I anti-CD45 radioimmunotherapy effectively targets and treats T-cell non-Hodgkin lymphoma Blood, June 4, 2009; 113(23): 5905 - 5910. [Abstract] [Full Text] [PDF] P. T. Bradford, S. S. Devesa, W. F. Anderson, and J. R. Toro Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases Blood, May 21, 2009; 113(21): 5064 - 5073. [Abstract] [Full Text] [PDF] M. Nakagawa, A. Nakagawa-Oshiro, S. Karnan, H. Tagawa, A. Utsunomiya, S. Nakamura, I. Takeuchi, K. Ohshima, and M. Seto Array Comparative Genomic Hybridization Analysis of PTCL-U Reveals a Distinct Subgroup with Genetic Alterations Similar to Lymphoma-Type Adult T-Cell Leukemia/Lymphoma Clin. Cancer Res., January 1, 2009; 15(1): 30 - 38. [Abstract] [Full Text] [PDF] R. W.J. Groen, M. E.C.M. Oud, E. J.M. Schilder-Tol, M. B. Overdijk, D. ten Berge, R. Nusse, M. Spaargaren, and S. T. Pals Illegitimate WNT Pathway Activation by {beta}-Catenin Mutation or Autocrine Stimulation in T-Cell Malignancies Cancer Res., September 1, 2008; 68(17): 6969 - 6977. [Abstract] [Full Text] [PDF] S. Kako, K. Izutsu, Y. Ota, Y. Minatani, M. Sugaya, T. Momose, K. Ohtomo, Y. Kanda, S. Chiba, T. Motokura, et al. FDG-PET in T-cell and NK-cell neoplasms Ann. Onc., October 1, 2007; 18(10): 1685 - 1690. [Abstract] [Full Text] [PDF] J. P. Greer Therapy of Peripheral T/NK Neoplasms Hematology, January 1, 2006; 2006(1): 331 - 337. [Abstract] [Full Text] [PDF]

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