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 Blood, 15 February 2006, Vol. 107, No. 4, pp. 1255-1264.
Prepublished online as a Blood First Edition Paper on October 6, 2005; DOI 10.1182/blood-2005-03-1306.

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Submitted March 30, 2005
Accepted August 16, 2005

T-cell non-Hodgkin's lymphoma

Mujahid A Rizvi*, Andrew M Evens, Martin S Tallman, Beverly P Nelson, and Steven T Rosen

Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; The Robert H. Lurie Comprehensive Cancer Center, Chicago, IL, USA
Division of Hematopathology, Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

* Corresponding author; email: m-rizvi{at}md.northwestern.edu.

T-cell non-Hodgkin's lymphomas (NHL) are uncommon malignancies. The current WHO/EORTC classification recognizes 9 distinct clinico-pathologic peripheral T-cell NHLs. These disorders have unique characteristics and require individualized diagnostic and therapeutic strategies. In recent years there has been tremendous progress in the understanding of the pathogenesis of these disorders. Specific chromosomal translocations and viral infections are now known to be associated with certain lymphomas. In this review, we describe both the clinical and pathologic features. We also discuss the use of molecular studies in the diagnostic work-up of T-cell lymphomas. Due to the rarity of these disorders and the lack of well-designed clinical trials, the treatment of peripheral T-cell NHLs is often challenging. In conclusion, further studies are required to learn more about the biology of these diseases, which may lead to more optimal and possibly targeted therapies.


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