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Blood, 1 November 2005, Vol. 106, No. 9, pp. 3123-3126.
Prepublished online as a Blood First Edition Paper on July 14, 2005; DOI 10.1182/blood-2005-03-1338.


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Submitted April 4, 2005
Accepted June 30, 2005

CD molecules 2005: human cell differentiation molecules

Heddy Zola*, Bernadette Swart, Ian Nicholson, Bent Aasted, Armand Bensussan, Laurence Boumsell, Chris Buckley, Georgina Clark, Karel Drbal, Pablo Engel, Derek Hart, Vaclav Horejsi, Clare Isacke, Peter Macardle, Fabio Malavasi, David Mason, Daniel Olive, Armin Saalmueller, Stuart F Schlossman, Reinhard Schwartz-Albiez, Paul Simmons, Thomas F Tedder, Mariagrazia Uguccioni, and Hilary Warren

Child Health Research Institute, Women's and Children's Hospital, Adelaide, South Australia, Australia
Immunology Laboratory, Department of Veterinary Patobiology, Royal Veterinary and Agriculture University, Stigbojlen, Denmark
Faculte de Medicine de Creteil INSERM 448 8, Creteil Cedex, France
Dept. of Rheumatology, Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Edgbaston, United Kingdom
Mater Medical Research Institute, Mater Hospital, Brisbane, Queensland, Australia
Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic
Immunology Department, Cellular Biology and Pathology Medical School, University of Barcelona, Barcelona, Spain
The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, Chester Beatty Laboratories, London, United Kingdom
Department of Immunology, Flinders Medical Centre, Adelaide, South Australia, Australia
Immunogenetics Laboratory, University of Torino Medical School, Torino, Italy
The Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, United Kingdom
Faculte de Medecine de Marseille and Centre Lutte Contre le Cancer, Laboratoire d'Immunologie des Tumeurs, Universite de la Mediterranee, Marseille, France
Klinische Immunologie, Klinisches Department fur diagnostische Verfahren, Veterinarmedizinische Universitat Wien, Vienna, Austria
Dana-Farber Cancer Institute, Boston, MA, USA
German Cancer Research Center, D010 Tumor Immunology, Heidelberg, Germany
Stem Cell Research Laboratories Peter MacCallum Cancer Institute, Melbourne, Victoria, Australia
Department of Immunology, Duke University Medical Center, Durham, NC, USA
Institute for Research in Biomedicine, Bellinzona, Switzerland
Division of Immunology and Genetics, John Curtin School of Medical Research, Australian National University, Canberra, Australia

* Corresponding author; email: heddy.zola{at}adelaide.edu.au.

The immune system works through leucocytes interacting with each other, with other cells, with tissue matrices, with infectious agents and with other antigens. These interactions are mediated by cell surface glycoproteins and glycolipids. Antibodies against these leucocyte molecules have provided powerful tools for analysis of their structure, function and distribution. Antibodies have been used widely in haematology, immunology and pathology, and in research, diagnosis and therapy. The associated CD nomenclature is commonly used when referring to leucocyte surface molecules and antibodies against them. It provides an essential classification for diagnostic and therapeutic purposes. The most recent (8th) Workshop and Conference on Human Leucocyte Differentiation Antigens (HLDA), held in Adelaide in December 2004, allocated 95 new CD designations and made radical changes to its aims and future operational strategy in order to maintain its relevance to modern human biology and clinical practice.


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