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Blood, 15 September 2005, Vol. 106, No. 6, pp. 1901-1910. Prepublished online as a Blood First Edition Paper on May 12, 2005; DOI 10.1182/blood-2005-04-1417. This Article Full Text (PDF) All Versions of this Article: 2005-04-1417v1 106/6/1901    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lapidot, T. Articles by Kollet, O. Search for Related Content PubMed PubMed Citation Articles by Lapidot, T. Articles by Kollet, O. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 7, 2005 Accepted May 6, 2005 How do stem cells find their way home? Tsvee Lapidot*, Ayelet Dar, and Orit Kollet Dept. of Immunology, Weizmann Institute, Rehovot, Israel * Corresponding author; email: Tsvee.Lapidot{at}weizmann.ac.il. Migration of hematopoietic stem cells through the blood, across the endothelial vasculature to different organs and to their BM niches, requires active navigation, a process termed homing. Homing is a rapid process and is the first and essential step in clinical stem cell transplantation. Similarly, homing is required for seeding of the fetal BM by hematopoietic progenitors during development. Homing has physiological roles in adult BM homeostasis, which are amplified during stress-induced recruitment of leukocytes from the BM reservoir and during stem cell mobilization, as part of host defense and repair. Homing is thought to be a coordinated, multi step process, which involves signaling by SDF-1 and SCF, activation of LFA-1, VLA-4/5 and CD44, cytoskeleton rearrangement, MT1-MMP activation and secretion of MMP2/9. Rolling and firm adhesion of progenitors to endothelial cells in small marrow sinusoids under blood flow is followed by trans-endothelial migration across the physical endothelium/ECM barrier. Stem cells finalize their homing uniquely, by selective access and anchorage to their specialized niches in the extravascular space of the endosteum region and in peri-arterial sites. This review is focused on mechanisms and key regulators of human stem cell homing to the BM in experimental animal models and clinical transplantation protocols. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. Bressler, A. R. Folsom, D. J. Couper, K. A. Volcik, and E. Boerwinkle Genetic Variants Identified in a European Genome-Wide Association Study That Were Found to Predict Incident Coronary Heart Disease in the Atherosclerosis Risk in Communities Study Am. J. Epidemiol., December 2, 2009; (2009) kwp377v1. 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