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Blood, 1 February 2006, Vol. 107, No. 3, pp. 1108-1115. Prepublished online as a Blood First Edition Paper on October 4, 2005; DOI 10.1182/blood-2005-04-1492. This Article Full Text (PDF) All Versions of this Article: 2005-04-1492v1 107/3/1108    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Narducci, M. G Articles by Russo, G. Search for Related Content PubMed PubMed Citation Articles by Narducci, M. G Articles by Russo, G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 12, 2005 Accepted September 18, 2005 Skin-homing of Sezary cells involves SDF-1-CXCR4 signaling and downregulation of CD26/dipeptidylpeptidase IV Maria G Narducci*, Enrico Scala, Antonella Bresin, Elisabetta Caprini, Maria C Picchio, Daniele Remotti, Gianluca Ragone, Francesca Nasorri, Marina Frontani, Diego Arcelli, Stefano Volinia, Giuseppe A Lombardo, Giannandrea Baliva, Monica Napolitano, and Giandomenico Russo Istituto Dermopatico dell'Immacolata, IDI - IRCCS. Laboratorio di Oncologia Molecolare, III e V Divisione Dermatologica, Laboratorio di Immunologia e Laboratorio di Patologia Vascolare, Rome, Italy Azienda Ospedaliera San Camillo-Forlanini, Rome, Italy Dipartimento di Morfologia ed Embriologia, Universita' di Ferrara, Ferrara, Italy * Corresponding author; email: narducci{at}idi.it. Sezary Syndrome (SS) is a rare form of Cutaneous T-Cell Lymphoma (CTCL) characterised by a distinct metastatic pattern mainly involving blood and skin. Chemokines and their receptors play a critical role in cellular recruitment and homing to tissues and in the metastatic process of several tumors including non-Hodgkin T-cell lymphomas (NHL). Here we report that SS cells express a functionally active CXCR4 and that its ligand SDF-1 is abundantly produced in the skin, which represents the main destination of SS cells spreading. SDF-1 is normally inactivated by proteolytic cleavage by the CD26/dipeptidylpeptidase IV (DPPIV). The lack of CD26 from the cell surface is a hallmark of circulating SS cells. We also show that the CD26 negative phenotype is maintained also in skin-infiltrating neoplastic T lymphocytes and that SS-affected individuals exhibit a reduced activity of plasma soluble CD26. Finally, we observe that the addition of soluble CD26 reduces the migratory response of SS cells to SDF-1 whereas the inhibition of the CD26 peptidase activity in Hut78, a CD26-positive CTCL cell line, enhances the SDF-1-induced migration of these cells. Our findings suggest that the SDF-1-CXCR4 axis could play an important role in skin homing of SS through the regulatory activity of CD26. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Caprini, C. Cristofoletti, D. Arcelli, P. Fadda, M. H. Citterich, F. Sampogna, A. Magrelli, F. Censi, P. Torreri, M. Frontani, et al. Identification of Key Regions and Genes Important in the Pathogenesis of Sezary Syndrome by Combining Genomic and Expression Microarrays Cancer Res., November 1, 2009; 69(21): 8438 - 8446. [Abstract] [Full Text] [PDF] S. Post, A. M. Smits, A. J. van den Broek, J. P.G. Sluijter, I. E. Hoefer, B. J. Janssen, R. J. Snijder, J. J. Mager, G. Pasterkamp, C. L. Mummery, et al. Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance Cardiovasc Res, October 8, 2009; (2009) cvp313v2. [Abstract] [Full Text] [PDF] C. Hoeller, S. K. Richardson, L. G. Ng, T. Valero, M. Wysocka, A. H. Rook, and W. Weninger In vivo Imaging of Cutaneous T-Cell Lymphoma Migration to the Skin Cancer Res., April 1, 2009; 69(7): 2704 - 2708. [Abstract] [Full Text] [PDF] M. C. Picchio, E. Scala, D. Pomponi, E. Caprini, M. Frontani, I. Angelucci, A. Mangoni, C. Lazzeri, M. Perez, D. Remotti, et al. CXCL13 Is Highly Produced by Sezary Cells and Enhances Their Migratory Ability via a Synergistic Mechanism Involving CCL19 and CCL21 Chemokines Cancer Res., September 1, 2008; 68(17): 7137 - 7146. [Abstract] [Full Text] [PDF] C. J. Lee, J. Dosch, and D. M. Simeone Pancreatic Cancer Stem Cells J. Clin. Oncol., June 10, 2008; 26(17): 2806 - 2812. [Abstract] [Full Text] [PDF] J. Xu, A. Mora, H. Shim, A. Stecenko, K. L. Brigham, and M. Rojas Role of the SDF-1/CXCR4 Axis in the Pathogenesis of Lung Injury and Fibrosis Am. J. Respir. Cell Mol. Biol., September 1, 2007; 37(3): 291 - 299. [Abstract] [Full Text] [PDF] V. Preller, A. Gerber, S. Wrenger, M. Togni, D. Marguet, J. Tadje, U. Lendeckel, C. Rocken, J. Faust, K. Neubert, et al. TGF-beta1-Mediated Control of Central Nervous System Inflammation and Autoimmunity through the Inhibitory Receptor CD26 J. Immunol., April 1, 2007; 178(7): 4632 - 4640. [Abstract] [Full Text] [PDF]

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