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Blood, 1 February 2006, Vol. 107, No. 3, pp. 1024-1030. Prepublished online as a Blood First Edition Paper on October 13, 2005; DOI 10.1182/blood-2005-04-1493. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-04-1493v1 107/3/1024    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kim, S. Articles by Yokoyama, W. M Search for Related Content PubMed PubMed Citation Articles by Kim, S. Articles by Yokoyama, W. M Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 12, 2005 Accepted September 25, 2005 Arrested natural killer cell development associated with transgene insertion into the Atf2 locus Sungjin Kim, Yun-Jeong Song, Darryl A Higuchi, Hyunseok P Kang, Jennifer R Pratt, Liping Yang, Caron M Hong, Jennifer Poursine-Laurent, Koho Iizuka, Anthony R French, John B Sunwoo, Shunsuke Ishii, Andreas M Reimold, and Wayne M Yokoyama* Howard Hughes Medical Institute, St. Louis, MO, USA; Rheumatology Division, Departments of Medicine and of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA Howard Hughes Medical Institute, St. Louis, MO, USA Howard Hughes Medical Institute, St. Louis, MO, USA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA Howard Hughes Medical Institute, St. Louis, MO, USA; Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO, USA Laboratory of Molecular Genetics, RIKEN Tsukuba Institute, Tsukuba, Ibaraki, Japan Rheumatic Diseases Division, University of Texas Southwestern Medical Center, Dallas, TX, USA * Corresponding author; email: yokoyama{at}im.wustl.edu. Natural killer (NK) cell development in the bone marrow is not fully understood. Following lineage commitment, these cells appear to advance through a series of developmental stages that are beginning to be characterized. We previously reported a selective deficiency of NK cells in a C57BL/6 mouse with a transgenic construct consisting of the cDNA for the Ly49A MHC class I-specific inhibitory receptor driven by the granzyme A gene. This mouse has few NK cells in peripheral tissues with relative preservation of other immune cells, including T and B cells. Herein we demonstrate that these mice have an accumulation of NK cells with an immature phenotype in the bone marrow, consistent with a block at a previously proposed stage in normal NK cell development. The phenotype is associated with transgenic insertion into Atf2, the gene for the basic leucine zipper (bZIP) transcription factor family member, ATF-2. Although analysis of Atf2-null NK cells show no defect, the transgenic mice express abnormal truncated Atf2 transcripts that may mediate a repressor effect because ATF2 can heterodimerize with other bZIP molecules. The defect is cell intrinsic, suggesting that certain bZIP molecules play significant roles in NK cell development. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: V. J. Lawson, D. Maurice, J. D. Silk, V. Cerundolo, and K. Weston Aberrant Selection and Function of Invariant NKT Cells in the Absence of AP-1 Transcription Factor Fra-2 J. Immunol., August 15, 2009; 183(4): 2575 - 2584. [Abstract] [Full Text] [PDF] O. Sobolev, P. Stern, A. Lacy-Hulbert, and R. O. Hynes Natural Killer Cells Require Selectins for Suppression of Subcutaneous Tumors Cancer Res., March 15, 2009; 69(6): 2531 - 2539. [Abstract] [Full Text] [PDF] J. B. Sunwoo, S. Kim, L. Yang, T. Naik, D. A. Higuchi, J. L. Rubenstein, and W. M. Yokoyama Distal-less homeobox transcription factors regulate development and maturation of natural killer cells PNAS, August 5, 2008; 105(31): 10877 - 10882. [Abstract] [Full Text] [PDF] J. S. Palumbo, K. E. Talmage, J. V. Massari, C. M. La Jeunesse, M. J. Flick, K. W. Kombrinck, Z. Hu, K. A. Barney, and J. L. Degen Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms Blood, July 1, 2007; 110(1): 133 - 141. [Abstract] [Full Text] [PDF] A. K. Parker, S. Parker, W. M. Yokoyama, J. A. Corbett, and R. M. L. Buller Induction of Natural Killer Cell Responses by Ectromelia Virus Controls Infection J. Virol., April 15, 2007; 81(8): 4070 - 4079. [Abstract] [Full Text] [PDF] T. Walzer, M. Blery, J. Chaix, N. Fuseri, L. Chasson, S. H. Robbins, S. Jaeger, P. Andre, L. Gauthier, L. Daniel, et al. Identification, activation, and selective in vivo ablation of mouse NK cells via NKp46 PNAS, February 27, 2007; 104(9): 3384 - 3389. [Abstract] [Full Text] [PDF]

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