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Blood, 15 October 2005, Vol. 106, No. 8, pp. 2862-2864. Prepublished online as a Blood First Edition Paper on June 28, 2005; DOI 10.1182/blood-2005-04-1515. This Article Full Text (PDF) All Versions of this Article: 2005-04-1515v1 106/8/2862    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Goerttler, P. S Articles by Pahl, H. L Search for Related Content PubMed PubMed Citation Articles by Goerttler, P. S Articles by Pahl, H. L Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 14, 2005 Accepted June 14, 2005 The Jak2V617F mutation, PRV-1 overexpression and EEC formation define a similar cohort of MPD patients Philipp S Goerttler, Cordula Steimle, Edith Marz, Peter L Johansson, Bjorn Andreasson, Martin Griesshammer, Heinz Gisslinger, Hermann Heimpel, and Heike L Pahl* Department of Experimental Anaesthesiology, University Hospital Freiburg, Freiburg, Germany Department of Medicine, University of Goteborg, Goteborg, Sweden Department of Medicine III, University Hospital Ulm, Ulm, Germany Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria Department of Experimental Anaesthesiology, University Hospital Freiburg, Freiburg, Germany; Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria * Corresponding author; email: pahl{at}uni-freiburg.de. Recently, a Jak2V617F mutation has been described in the vast majority of patients with polycythemia vera (PV) as well as in subsets of patients with essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF). The question arises whether this mutation is observed in that subset of ET and IMF patients which carries previously described molecular markers, notably the ability to form endogenous erythroid colonies (EECs), overexpression of PRV-1 and decreased c-Mpl expression. We therefore analyzed the Jak2 DNA sequence, EEC growth, PRV-1 expression and c-Mpl levels in a cohort of 78 MPD patients (42 ET, 22 PV and 14 IMF). Presence of the Jak2V617F mutation was very highly correlated with PRV-1 overexpression and the ability to form EECs in all three subtypes of MPD (p<0.0001). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Let's not get too JAKed up! Ronald Hoffman Blood 2005 106: 2599. 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