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Blood, 15 November 2005, Vol. 106, No. 10, pp. 3358-3365. Prepublished online as a Blood First Edition Paper on July 28, 2005; DOI 10.1182/blood-2005-04-1535. This Article Full Text (PDF) All Versions of this Article: 2005-04-1535v1 106/10/3358    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hill, D. A Articles by Travis, L. B Search for Related Content PubMed PubMed Citation Articles by Hill, D. A Articles by Travis, L. B Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 15, 2005 Accepted July 14, 2005 Breast cancer risk following radiotherapy for Hodgkin lymphoma: modification by other risk factors Deirdre A Hill*, Ethel Gilbert, Graca M Dores, Mary Gospodarowicz, Flora E van Leeuwen, Eric Holowaty, Bengt Glimelius, Michael Andersson, Tom Wiklund, Charles F Lynch, Mars van't Veer, Hans Storm, Eero Pukkala, Marilyn Stovall, Rochelle E Curtis, James M Allan, John D Boice, and Lois B Travis Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA; Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA Division of Cancer Epidemiology and Genetics and Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD, USA Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada Netherlands Cancer Institute, Amsterdam, The Netherlands Cancer Care Ontario, Toronto, Ontario, Canada Uppsala University, Uppsala, Sweden Danish Cancer Society, Copenhagen, Denmark Helsinki University Central Hospital, Helsinki, Finland University of Iowa, Iowa City, Iowa, USA The Dr. Daniel Den Hoed Cancer Center, Rotterdam, The Netherlands Finnish Cancer Registry, Helsinki, Finland University of Texas M.D. Anderson Cancer Center, Houston, TX, USA Epidemiology and Genetics Unit, University of York, York, United Kingdom International Epidemiology Institute, Rockville, MD, USA; Vanderbilt University Medical Center, Nashville, TN, USA * Corresponding author; email: dahill{at}salud.unm.edu. The importance of genetic and other risk factors in the development of breast cancer after radiotherapy (RT) for Hodgkin lymphoma (HL) has not been determined. We analyzed data from a breast cancer case-control study (105 cases, 266 controls) conducted among 3,817 survivors of HL diagnosed at age 30 years in six population-based cancer registries. Odds ratios (OR) and excess relative risks (ERR) were calculated using conditional regression. Women who received RT exposure ( 5 Gray (Gy) radiation dose to the breast) had a 2.7-fold increased breast cancer risk (95% confidence interval (CI) 1.4-5.2), compared with those given < 5 Gy. RT exposure ( 5 Gy) was associated with an OR of 0.8 (95% CI, 0.2-3.4) among women with a first- or second-degree family history of breast or ovarian cancer, and 5.8 (95% CI, 2.1-16.3) among all other women (interaction p-value=.03). History of a live birth appeared to increase the breast cancer risk associated with RT among women not treated with ovarian-damaging therapies. Breast cancer risk following RT varied little according to other factors. The additional increased relative risk of breast cancer after RT for HL is unlikely to be larger among women with a family history of breast or ovarian cancer than among other women. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Crump and D. Hodgson Secondary Breast Cancer in Hodgkin's Lymphoma Survivors J. Clin. Oncol., September 10, 2009; 27(26): 4229 - 4231. [Full Text] [PDF] C. M. Ronckers, M. M. Doody, J. E. Lonstein, M. Stovall, and C. E. Land Multiple Diagnostic X-rays for Spine Deformities and Risk of Breast Cancer Cancer Epidemiol. Biomarkers Prev., March 1, 2008; 17(3): 605 - 613. [Abstract] [Full Text] [PDF] D. L. Friedman, A. Rovo, W. Leisenring, A. Locasciulli, M. E. D. 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