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Blood, 1 July 2006, Vol. 108, No. 1, pp. 278-285. Prepublished online as a Blood First Edition Paper on January 12, 2006; DOI 10.1182/blood-2005-04-1567. This Article Full Text (PDF) All Versions of this Article: 2005-04-1567v1 108/1/278    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Niclot, S. Articles by Baudry-Bluteau, D. Search for Related Content PubMed PubMed Citation Articles by Niclot, S. Articles by Baudry-Bluteau, D. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 18, 2005 Accepted December 29, 2005 Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas Sidonie Niclot, Quentin Pruvot, Caroline Besson, Daniel Savoy, Elisabeth Macintyre, Gilles Salles, Nicole Brousse, Bruno Varet, Paul Landais, Pierre Taupin, Claudine Junien*, and Dominique Baudry-Bluteau Inserm UR383, Paris, France Service d'Hematologie Clinique Adulte, Hopital Necker-Enfants Malades, Universite Rene Descartes, Paris, France Laboratoire d'Hematologie, Hopital Necker-Enfants Malades, Universite Rene Descartes, Paris, France Service d'Hematologie-Centre Hospitalier Lyon Sud, Pierre-Benite, France Service d'Anatomo-pathologie, Hopital Necker-Enfants Malades, Universite Rene Descartes, Paris, France Departement de biostatistiques, Hopital Necker-Enfants Malades, Universite Rene Descartes, Paris, France * Corresponding author; email: junien{at}necker.fr. The incidence of follicular lymphoma (FL) in industrialized countries has been increasing since the 1950s. Polymorphisms in genes encoding key enzymes controlling folate-methionine metabolism including methylenetetrahydrofolate reductase (MTHFR), methionine synthase, (MS/MTR), serine hydroxymethyl transferase (SHMT) and thymidylate synthase (TS/TYMS) modify the risk of various cancers, and possibly FL. This study is specifically looking for an association between MTHFR, MTR, TYMS and SHMT polymorphisms and the risk of FL. We carried out a case-control study with 172 patients diagnosed with FL and 206 control subjects. We report that the risk of FL was doubled by the association of one mutant allele at both MTHFR polymorphisms. MTR 2756AA individuals had 2-fold higher risk of FL and subjects not having at least one TYMS 2R allele showed a 2-fold higher risk of FL. The MTR 2756AA genotype conferred a greater multivariate-adjusted relative risk of FL, and the risk was multiplied by almost 5 in the TYMS2R(-)/MTR 2756AA combination. In conclusion, common polymorphisms in key enzymes of the folate-methionine metabolism pathway result in an increased risk of FL and suggest that inadequate intake of dietary folate and other methyl donor nutrients may contribute to the development of this malignancy. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study Unhee Lim, Sophia S. Wang, Patricia Hartge, Wendy Cozen, Linda E. Kelemen, Stephen Chanock, Scott Davis, Aaron Blair, Maryjean Schenk, Nathaniel Rothman, and Qing Lan Blood 2007 109: 3050-3059. [Abstract] [Full Text] [PDF] This article has been cited by other articles: C. F. Skibola, J. D. Curry, and A. Nieters Genetic susceptibility to lymphoma Haematologica, July 1, 2007; 92(7): 960 - 969. [Abstract] [Full Text] [PDF] U. Lim, S. S. Wang, P. Hartge, W. Cozen, L. E. Kelemen, S. Chanock, S. Davis, A. Blair, M. Schenk, N. Rothman, et al. Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER Case-Control Study Blood, April 1, 2007; 109(7): 3050 - 3059. [Abstract] [Full Text] [PDF]

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