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Blood, 15 November 2005, Vol. 106, No. 10, pp. 3632-3638. Prepublished online as a Blood First Edition Paper on July 26, 2005; DOI 10.1182/blood-2005-04-1574. This Article Full Text (PDF) All Versions of this Article: 2005-04-1574v1 106/10/3632    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Layez, C. Articles by Gysin, J. Search for Related Content PubMed PubMed Citation Articles by Layez, C. Articles by Gysin, J. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 18, 2005 Accepted July 13, 2005 Plasmodium falciparum rhoptry protein RSP2 triggers destruction of the erythroid lineage Corinne Layez, Paulo Nogueira, Valery Combes, Fabio T Costa, Irene Juhan-Vague, Luiz H Pereira da Silva, and Jurg Gysin* Unite de Parasitologie Experimentale URA Institut Pasteur/ Univ. Med. EA3282 IFR48, Faculte de Medecine, Universite de la Mediterranee, Marseille, France Unidade de Imunologia E Parasitologia Experimental, CEPEM Centro de Pesquisa em Medicina Tropical, Porto Velho, Rondonia, Brazil Departamento de Parasitologia, Universidade Estadual de Campinas, Campinas, Brazil Laboratoire d'Hematologie, Faculte de Medecine, Universite de la Mediterranee, Marseille, France * Corresponding author; email: gysin{at}medecine.univ-mrs.fr. The destruction of erythrocytes and defects in erythropoiesis are among the most frequently observed cause of morbidity in severe falciparum malaria. The molecular mechanisms involved remain unclear, despite extensive investigation. We show here, for the first time, that tagging with the parasite rhoptry protein RSP-2 is not restricted to the surface of normal erythrocytes, as previously reported, but also extends to erythroid precursor cells in the bone marrow of anemic malaria patients. Monoclonal mouse antibodies and human sera from patients with severe anemia, reacting with RSP2-tagged erythrocytes, induced cell destruction by phagocytosis and complement activation in vitro. Our observations reveal a new parasite mechanism implicated in the destruction of normal erythrocytes and probably dyserythropoiesis in malaria patients. These data suggest that the tagging of host cells with RSP-2 may trigger anemia in falciparum malaria. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Severe anemia in malaria: defense gone wrong? Gerhard Winter and Mats Wahlgren Blood 2005 106: 3337-3338. [Full Text] [PDF] This article has been cited by other articles: K. J.H. Robson and D. J. Weatherall Malarial anemia and STAT6 Haematologica, February 1, 2009; 94(2): 157 - 159. [Full Text] [PDF] I. Safeukui, J.-M. Correas, V. Brousse, D. Hirt, G. Deplaine, S. Mule, M. Lesurtel, N. Goasguen, A. Sauvanet, A. Couvelard, et al. Retention of Plasmodium falciparum ring-infected erythrocytes in the slow, open microcirculation of the human spleen Blood, September 15, 2008; 112(6): 2520 - 2528. [Abstract] [Full Text] [PDF] A. A. Lamikanra, D. Brown, A. Potocnik, C. Casals-Pascual, J. Langhorne, and D. J. Roberts Malarial anemia: of mice and men Blood, July 1, 2007; 110(1): 18 - 28. [Abstract] [Full Text] [PDF] J. W. Barnwell Malaria: death and disappearing erythrocytes Blood, February 1, 2006; 107(3): 854 - 855. [Full Text] [PDF] K. J. Evans, D. S. Hansen, N. van Rooijen, L. A. Buckingham, and L. Schofield Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes Blood, February 1, 2006; 107(3): 1192 - 1199. [Abstract] [Full Text] [PDF]

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