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Blood, 1 October 2005, Vol. 106, No. 7, pp. 2433-2435. Prepublished online as a Blood First Edition Paper on June 23, 2005; DOI 10.1182/blood-2005-04-1597. This Article Full Text (PDF) All Versions of this Article: 2005-04-1597v1 106/7/2433    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Roychowdhury, S. Articles by Caligiuri, M. A Search for Related Content PubMed PubMed Citation Articles by Roychowdhury, S. Articles by Caligiuri, M. A Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 22, 2005 Accepted May 30, 2005 IL-15 but not IL-2 rapidly induces lethal xenogeneic graft versus host disease Sameek Roychowdhury, Bradley W Blaser, Aharon G Freud, Kerry Katz, Darshna Bhatt, Amy K Ferketich, Valerie Bergdall, Donna Kusewitt, Robert A Baiocchi, and Michael A Caligiuri* Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA; Medical Scientist Program, The Ohio State University, Columbus, Ohio, USA Medical Scientist Program, The Ohio State University, Columbus, Ohio, USA; Integrated Biomedical Science Graduate Program, The Ohio State University, Columbus, Ohio, USA Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, Ohio, USA Division of Epidemiology and Biostatistics, The Ohio State University, Columbus, Ohio, USA Department of Veterinary Preventive Medicine, The Ohio State University, Columbus, Ohio, USA Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, Ohio, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, Ohio, USA; Department of Internal Medicine, Division of Hematology/Oncology, The Ohio State University, Columbus, Ohio, USA; Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA * Corresponding author; email: caligiuri-1{at}medctr.osu.edu. Interleukin-2 (IL-2) and IL-15 are structurally related cytokines that share receptor components but display markedly different effects in multiple in vivo model systems. Here we demonstrate that IL-15 but not IL-2 exacerbates xenogeneic graft-versus-host disease (X-GVHD) in severe combined immunodeficient murine recipients of human peripheral blood lymphocytes (hu-PBL-SCID). Treatment of hu-PBL-SCID mice with IL-15 resulted in rapid fatality, lymphocytic infiltrations in the liver, lung and spleen consistent with X-GVHD, and a marked expansion of human CD4+ and CD8+ T cells compared to controls. Depletion of human T cells in vivo abrogated the lethality of IL-15 treatment. To our knowledge, these data are the first to demonstrate in vivo activation and expansion of human T lymphocytes in response to IL-15 with concomitant exacerbation of human T cell-mediated X-GVHD. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Zorn and J. Ritz Studying Human Regulatory T Cells In vivo. Clin. Cancer Res., September 15, 2006; 12(18): 5265 - 5267. [Full Text] [PDF] E. Zorn, E. A. Nelson, M. Mohseni, F. Porcheray, H. Kim, D. Litsa, R. Bellucci, E. Raderschall, C. Canning, R. J. Soiffer, et al. IL-2 regulates FOXP3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo Blood, September 1, 2006; 108(5): 1571 - 1579. [Abstract] [Full Text] [PDF] G. H. Cornish, L. V. Sinclair, and D. A. Cantrell Differential regulation of T-cell growth by IL-2 and IL-15 Blood, July 15, 2006; 108(2): 600 - 608. [Abstract] [Full Text] [PDF] A. Sun, H. Wei, R. Sun, W. Xiao, Y. Yang, and Z. Tian Human Interleukin-15 Improves Engraftment of Human T Cells in NOD-SCID Mice Clin. Vaccine Immunol., February 1, 2006; 13(2): 227 - 234. [Abstract] [Full Text] [PDF]

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