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Blood, 1 December 2005, Vol. 106, No. 12, pp. 3854-3859. Prepublished online as a Blood First Edition Paper on August 16, 2005; DOI 10.1182/blood-2005-04-1658. This Article Full Text (PDF) All Versions of this Article: 2005-04-1658v1 106/12/3854    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jia, W. Articles by He, Y.-W. Search for Related Content PubMed PubMed Citation Articles by Jia, W. Articles by He, Y.-W. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 27, 2005 Accepted August 1, 2005 The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment Wei Jia, Hong Li, and You-Wen He* Department of Immunology, Duke University Medical Center, Durham, NC, USA * Corresponding author; email: he000004{at}mc.duke.edu. Leukocyte recruitment to inflammation sites depends on interactions between integrins and extracellular matrix (ECM). In this report, we show that mice lacking the ECM protein mindin exhibit severely impaired recruitment of neutrophils and macrophages in four different inflammation models. Furthermore, neutrophils directly bind to immobilized mindin and mindin matrix mediates neutrophil migration in vitro. The adhesion of neutrophils to mindin is blocked by anti-integrin 4, M and 2 antibodies. We also show that HEK-293 cells transfected with cDNA encoding these integrins exhibit enhanced binding to immobilized mindin matrix and the increased binding can be blocked by anti-integrin antibodies. Our results suggest that mindin serves as a novel ligand for integrins and mindin-integrin interactions are critical for inflammatory cell recruitment in vivo. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D G Downey, S C Bell, and J S Elborn Neutrophils in cystic fibrosis Thorax, January 1, 2009; 64(1): 81 - 88. [Abstract] [Full Text] [PDF] Z. Li, S. Garantziotis, W. Jia, E. N. Potts, S. Lalani, Z. Liu, Y.-W. He, W. M. Foster, and J. W. Hollingsworth The extracellular matrix protein mindin regulates trafficking of murine eosinophils into the airspace J. Leukoc. Biol., January 1, 2009; 85(1): 124 - 131. [Abstract] [Full Text] [PDF] W.-M. Woo, E. C. Berry, M. L. Hudson, R. E. Swale, A. Goncharov, and A. D. Chisholm The C. elegans F-spondin family protein SPON-1 maintains cell adhesion in neural and non-neural tissues Development, August 15, 2008; 135(16): 2747 - 2756. [Abstract] [Full Text] [PDF] Y. Zhang, X.-T. Bai, K.-Y. Zhu, Y. Jin, M. Deng, H.-Y. Le, Y.-F. Fu, Y. Chen, J. Zhu, A. T. Look, et al. In Vivo Interstitial Migration of Primitive Macrophages Mediated by JNK-Matrix Metalloproteinase 13 Signaling in Response to Acute Injury J. Immunol., August 1, 2008; 181(3): 2155 - 2164. [Abstract] [Full Text] [PDF] W. Jia, H. Li, and Y.-W. He Pattern Recognition Molecule Mindin Promotes Intranasal Clearance of Influenza Viruses J. Immunol., May 1, 2008; 180(9): 6255 - 6261. [Abstract] [Full Text] [PDF] Q.-Q. Wang, H. Li, T. Oliver, M. Glogauer, J. Guo, and Y.-W. He Integrin {beta}1 Regulates Phagosome Maturation in Macrophages through Rac Expression J. Immunol., February 15, 2008; 180(4): 2419 - 2428. [Abstract] [Full Text] [PDF]

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