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Blood, 15 March 2006, Vol. 107, No. 6, pp. 2531-2535. Prepublished online as a Blood First Edition Paper on November 29, 2005; DOI 10.1182/blood-2005-04-1768. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-04-1768v1 107/6/2531    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rigolin, G. M. Articles by Castoldi, G. Search for Related Content PubMed PubMed Citation Articles by Rigolin, G. M. Articles by Castoldi, G. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 2, 2005 Accepted November 8, 2005 Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion Gian Matteo Rigolin*, Chiara Fraulini, Maria Ciccone, Endri Mauro, Anna Maria Bugli, Cristiano De Angeli, Massimo Negrini, Antonio Cuneo, and Gianluigi Castoldi Hematology Section, Department of Biomedical Sciences, Azienda Ospedaliero-Universitaria Arcispedale S. Anna, University of Ferrara, Ferrara, Italy Microbiology Section, Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy; Centro interdipartimentale per la Ricerca sul Cancro, University of Ferrara, Ferrara, Italy * Corresponding author; email: rglgmt{at}unife.it. In multiple myeloma (MM), circulating endothelial cells (CECs) represent a vascular marker of angiogenesis and may reflect tumor mass. In this report, we showed that, in 5 MM patients with 13q14 deletion, CECs carried the same chromosome aberration as the neoplastic plasma cells (11-32% of CECs with 13q14 deletion). Most of CECs displayed immunophenotypic features of endothelial progenitor cells as they expressed CD133, a marker gradually lost during endothelial differentiation and absent on mature endothelial cells. To the contrary, in 3 patients with monoclonal gammopathy of undetermined significance and 13q14 deletion, CECs were cytogenetically normal and had a mature immunophenotype. In MM CECs, immunoglobulin genes were clonally rearranged. These findings suggest a possible origin of CECs from a common hemangioblast precursor that can give rise to both plasma cells and endothelial cells and point to a direct contribution of MM-derived CECs to tumor vasculogenesis and possibly to the spreading and progression of the disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. Ria, C. Piccoli, T. Cirulli, F. Falzetti, G. Mangialardi, D. Guidolin, A. Tabilio, N. Di Renzo, A. Guarini, D. Ribatti, et al. Endothelial Differentiation of Hematopoietic Stem and Progenitor Cells from Patients with Multiple Myeloma Clin. Cancer Res., March 15, 2008; 14(6): 1678 - 1685. [Abstract] [Full Text] [PDF] Y. Oki and A. Younes Endothelial progenitor cells in non-Hodgkin's lymphoma Haematologica, April 1, 2007; 92(4): 433 - 434. [Full Text] [PDF] A. Pezzolo, F. Parodi, M. V. Corrias, R. Cinti, C. Gambini, and V. Pistoia Tumor Origin of Endothelial Cells in Human Neuroblastoma J. Clin. Oncol., February 1, 2007; 25(4): 376 - 383. [Abstract] [Full Text] [PDF]

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