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Blood, 1 February 2006, Vol. 107, No. 3, pp. 1233-1236. Prepublished online as a Blood First Edition Paper on October 11, 2005; DOI 10.1182/blood-2005-05-1819. This Article Full Text (PDF) All Versions of this Article: 2005-05-1819v1 107/3/1233    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cooper, N. Articles by Amrolia, P. J Search for Related Content PubMed PubMed Citation Articles by Cooper, N. Articles by Amrolia, P. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 5, 2005 Accepted September 18, 2005 Stem cell transplantation with reduced intensity conditioning for haemophagocytic lymphohistiocytosis Nichola Cooper, Kanchan Rao, Kimberly Gilmour, Lema Hadad, Stuart Adams, Cathy Cale, Graham Davies, David Webb, Paul Veys, and Persis J Amrolia* Bone marrow transplant, haematology and molecular immunology, Great Ormond Street Hospital, London, United Kingdom * Corresponding author; email: amrolp1{at}gosh.nhs.uk. Allogeneic stem cell transplant (SCT) is curative for haemophagocytic lymphohistiocytosis (HLH). However, patients frequently have significant pre-transplant morbidity and there is high transplant related mortality (TRM). Because primary HLH is caused by immune dysregulation, a reduced intensity conditioned (RIC) regimen might be sufficient for cure, while decreasing the TRM. 12 patients with HLH underwent RIC SCT from a matched family/unrelated or haploidentical donor. 11 were conditioned with fludarabine/melphalan with additional busulphan for haplo-identical grafts. 1 received fludarabine and 2GyTBI. All patients engrafted at a median of 14 days. 9 of 12(75%) are alive and in CR a median of 30 (range 9 to 73) months post SCT. 3 died from pneumonitis (n=2) and hepatic rupture (n=1). 4 developed acute GVHD and 3 have chronic GVHD. 3 of 9 survivors have mixed chimerism but remain disease-free. In summary, RIC compares favorably to conventional SCT with long-term disease control in surviving patients despite a significant incidence of mixed chimerism. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. I. Cohen, H. Kimura, S. Nakamura, Y.-H. Ko, and E. S. Jaffe Epstein-Barr virus-associated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8-9 September 2008 Ann. Onc., September 1, 2009; 20(9): 1472 - 1482. [Abstract] [Full Text] [PDF] M. A. Pulsipher, K. M. Boucher, D. Wall, H. Frangoul, M. Duval, R. K. Goyal, P. J. Shaw, A. E. Haight, M. Grimley, S. A. Grupp, et al. Reduced-intensity allogeneic transplantation in pediatric patients ineligible for myeloablative therapy: results of the Pediatric Blood and Marrow Transplant Consortium Study ONC0313 Blood, August 13, 2009; 114(7): 1429 - 1436. [Abstract] [Full Text] [PDF] J. Pachlopnik Schmid, D. Moshous, N. Boddaert, B. Neven, L. Dal Cortivo, M. Tardieu, M. Cavazzana-Calvo, S. Blanche, G. de Saint Basile, and A. Fischer Hematopoietic stem cell transplantation in Griscelli syndrome type 2: a single-center report on 10 patients Blood, July 2, 2009; 114(1): 211 - 218. [Abstract] [Full Text] [PDF] S. Cesaro, F. Locatelli, E. Lanino, F. Porta, L. Di Maio, C. Messina, A. Prete, M. Ripaldi, N. Maximova, G. Giorgiani, et al. Hematopoietic stem cell transplantation for hemophagocytic lymphohistiocytosis: a retrospective analysis of data from the Italian Association of Pediatric Hematology Oncology (AIEOP) Haematologica, November 1, 2008; 93(11): 1694 - 1701. [Abstract] [Full Text] [PDF]

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