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Blood, 15 December 2005, Vol. 106, No. 13, pp. 4054-4056. Prepublished online as a Blood First Edition Paper on August 25, 2005; DOI 10.1182/blood-2005-05-1866. This Article Full Text (PDF) All Versions of this Article: 2005-05-1866v1 106/13/4054    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gleissner, B. Articles by Thiel, E. Search for Related Content PubMed PubMed Citation Articles by Gleissner, B. Articles by Thiel, E. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 10, 2005 Accepted August 11, 2005 CD10-negative pre-B acute lymphoblastic leukemia (ALL): a distinct high-risk subgroup of adult ALL associated with a high frequency of MLL aberrations. Results of the German Multicenter Trials for Adult ALL (GMALL) Beate Gleissner*, Nicola Goekbuget, Harald Rieder, Renate Arnold, Stefan Schwartz, Helmut Diedrich, Claudia Schoch, Barbara Heinze, Christa Fonatsch, Claus R Bartram, Dieter Hoelzer, and Eckhard Thiel Internal Medicine III, Charite Universitaetsmedizin, Campus Benjamin Franklin, Berlin, Germany Department of Hematology, Goethe University, Frankfurt, Germany Institute of Human Genetics and Anthropology, Heinrich-Heine University, Duesseldorf, Germany Department of Hematology and Oncology, Charite Universitaetsmedizin, Campus Virchow, Berlin, Germany Department of Hematology and Oncology, Medical University, Hannover, Germany Department of Internal Medicine III, Laboratory for Leukemia-Diagnostics, University Hospital Grosshadern, Muenchen, Germany Laboratory for Tumor Cytogenetics, University of Ulm, Ulm, Germany Department of Human Genetics, KIMCL, Medical Institute for Medical Biology, University of Vienna, Vienna, Austria Insitute of Human Genetics, University of Heidelberg, Heidelberg, Germany * Corresponding author; email: beate.gleissner{at}charite.de. Immunophenotyping disclosed CD10-negativity in 70 of 2,408 cases of B-lineage acute lymphoblastic leukemia (ALL), although other criteria followed classification of pre-B ALL (e.g., cytoplasmic immunoglobulin positivity). These blasts showed high myeloid antigen expression (60% CD65-positivity) and reacted with antibody 7.1 in 95% of the cases. MLL-AF4 fusion transcripts and/or an 11q23/MLL rearrangement were evident in 46/56 samples (82%). Although 83% of the patients achieved complete remission, the remission duration remained remarkably low: 141 days for MLL-rearrangement-positive and 245 days for MLL-rearrangement-negative CD10-negative pre-B ALL. Thus the overall survival probability 3 years after diagnosis was 0.34 (± 0.20 SE) in MLL-rearrangement-negative versus 0.12 (± 0.06 SE) in MLL-rearrangement-positive CD10-negative pre-B ALL. Our data identify CD10-negative cytoplasmic Ig-positive pre-B ALL as a rare (2.2%) but distinct immunosubtype of adult ALL that is characterized by a high MLL rearrangement rate and a worse outcome. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Burmeister, C. Meyer, S. Schwartz, J. Hofmann, M. Molkentin, E. Kowarz, B. Schneider, T. Raff, R. Reinhardt, N. Gokbuget, et al. The MLL recombinome of adult CD10-negative B-cell precursor acute lymphoblastic leukemia: results from the GMALL study group Blood, April 23, 2009; 113(17): 4011 - 4015. [Abstract] [Full Text] [PDF] A. Attarbaschi, G. Mann, M. Konig, M. Steiner, S. Strehl, A. Schreiberhuber, B. Schneider, C. Meyer, R. Marschalek, A. Borkhardt, et al. Mixed Lineage Leukemia-Rearranged Childhood Pro-B and CD10-Negative Pre-B Acute Lymphoblastic Leukemia Constitute a Distinct Clinical Entity. Clin. Cancer Res., May 15, 2006; 12(10): 2988 - 2994. [Abstract] [Full Text] [PDF]

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