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 Blood, 1 January 2006, Vol. 107, No. 1, pp. 106-110.
Prepublished online as a Blood First Edition Paper on September 20, 2005; DOI 10.1182/blood-2005-05-1955.

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Submitted May 16, 2005
Accepted August 29, 2005

Runx1 function in hematopoiesis is required in cells that express Tek

Zhe Li, Michael J Chen, Terryl Stacy, and Nancy A Speck*

Department of Biochemistry, Dartmouth Medical School, Hanover, NH, USA

* Corresponding author; email: nancy.speck{at}dartmouth.edu.

Runx1 expression marks the putative hemogenic endothelium between embryonic days (E) 8.5-11.5 of mouse gestation and is required for the formation of intra-aortic hematopoietic clusters, leading to the hypothesis that Runx1 is required for the transition from endothelial to hematopoietic cell. To address this hypothesis, we ablated the Runx1 gene by Cre-recombinase-mediated excision, with Cre expression under the control of the Tek promoter and enhancer. Most embryos died between E12.5-13.5 with a phenotype almost identical to Runx1 deficiency. We conclude that Runx1 function in establishing definitive hematopoiesis is required in a Tek+ cell.


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