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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1528-1536. Prepublished online as a Blood First Edition Paper on October 20, 2005; DOI 10.1182/blood-2005-05-2073. This Article Full Text (PDF) All Versions of this Article: 2005-05-2073v1 107/4/1528    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hirano, N. Articles by Nadler, L. M Search for Related Content PubMed PubMed Citation Articles by Hirano, N. Articles by Nadler, L. M Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 23, 2005 Accepted October 11, 2005 Engagement of CD83 ligand induces prolonged expansion of CD8+ T cells and preferential enrichment for antigen specificity Naoto Hirano*, Marcus O Butler, Zhinan Xia, Sascha Ansen, Michael S von Bergwelt-Baildon, Donna Neuberg, Gordon J Freeman, and Lee M Nadler Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA Department of Biostatics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA, USA * Corresponding author; email: Naoto_HIrano{at}dfci.harvard.edu. Following T cell receptor and CD28 signaling, CD8+ T cells express a receptor for CD83, a molecule upregulated on functionally mature dendritic cells. Though this expression pattern suggests that CD83 is involved in adaptive immunity, little is known about its function in the periphery, and the existence of its ligand on T cells is controversial. We demonstrate that the engagement of the CD83 ligand preferentially enriches and significantly amplifies the number of antigen-specific CD8+ T cells. Coengagement of the T cell receptor, CD28, and CD83 ligand supports priming of naive CD8+ T cells that retain antigen specificity and cytotoxic function for greater than 6 months. Therefore, engagement of the CD83 ligand provides a unique signal to activated CD8+ T cells that could be exploited to generate long-lived antigen specific cytotoxic T cells for the treatment of cancer and infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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