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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1421-1426. Prepublished online as a Blood First Edition Paper on November 3, 2005; DOI 10.1182/blood-2005-05-2112. This Article Full Text (PDF) All Versions of this Article: 2005-05-2112v1 107/4/1421    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fuhlbrigge, R. C Articles by Kupper, T. S Search for Related Content PubMed PubMed Citation Articles by Fuhlbrigge, R. C Articles by Kupper, T. S Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 26, 2005 Accepted September 18, 2005 CD43 is a ligand for E-selectin on CLA+ human T cells Robert C Fuhlbrigge*, Sandra L King, Robert Sackstein, and Thomas S Kupper Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA * Corresponding author; email: rfuhlbrigge{at}partners.org. The recruitment of memory T cells from blood into tissues is a central element of immune surveillance and adaptive immune responses and a key feature of chronic cutaneous inflammatory diseases such as psoriasis and atopic dermatitis. Human memory T cells that infiltrate skin express the carbohydrate epitope cutaneous lymphocyte-associated antigen (CLA). Expression of the CLA epitope on T cells has been described on P-selectin glycoprotein ligand-1 (PSGL-1) and associated with the acquisition of both E-selectin and P-selectin ligand functions. In this report, we show that CD43, a sialomucin expressed constitutively on T cells, can also be decorated with the CLA epitope and serve as an E-selectin ligand. CLA expressed on CD43 was found exclusively on the high molecular weight (125 kD) glycoform bearing core-2 branched O-linked glycans. CLA+ CD43 purified from human T cells supported tethering and rolling in shear flow via E-selectin but did not support binding of P-selectin. The identification and characterization of CD43 as a T cell E-selectin ligand distinct from PSGL-1 expands the role of CD43 in the regulation of T cell trafficking and provides new targets for the modulation of immune functions in skin. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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