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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1624-1626.
Prepublished online as a Blood First Edition Paper on October 27, 2005; DOI 10.1182/blood-2005-05-2131.


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Submitted May 26, 2005
Accepted October 12, 2005

Radiofrequency ablation of lymphoma

Deepak Sudheendra, Mara M Barth, Upendra Hegde, Wyndham H Wilson, and Bradford J Wood*

Department of Radiology, National Institutes of Health, Bethesda, MD, USA
Department of Radiology, Beth Israel Deaconness Medical Center, Boston, MA, USA
Department of Hematology, University of Connecticut Health Center, Farmington, CT, USA
Medicine Branch, National Cancer Institute, Bethesda, MD, USA

* Corresponding author; email: bwood{at}nih.gov.

Percutaneous minimally invasive radiofrequency (RF) ablation has not been described for lymphoma. This image-guided modality is presented in three different settings for the treatment of refractory lymphoma. The first patient received RF ablation for the curative treatment of a solitary residual hepatic mass following rituximab-based chemotherapy for a post-transplant lymphoproliferative disorder, and is disease-free four years later. The second patient received RF ablation for successful palliation of progressive follicular lymphoma adjacent to the bladder wall following chemotherapy and maximum radiation. The third patient received RF ablation for prevention of airway obstruction from progressive diffuse large B-cell lymphoma of the right neck following chemotherapy and maximum radiation. RF ablation may be clinically beneficial and should be considered for the treatment of local lymphoma that is refractory or not amenable to standard approaches.


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