Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 January 2006, Vol. 107, No. 1, pp. 143-150.
Prepublished online as a Blood First Edition Paper on September 15, 2005; DOI 10.1182/blood-2005-06-2218.

This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Figure
Right arrow All Versions of this Article:
2005-06-2218v1
107/1/143    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Edelson, B. T
Right arrow Articles by Zutter, M. M
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Edelson, B. T
Right arrow Articles by Zutter, M. M
Related Collections
Right arrowRelated Article in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted June 2, 2005
Accepted August 22, 2005

A novel collectin/C1q receptor mediates mast cell activation and innate immunity

Brian T Edelson, Thomas P Stricker, Zhengzhi Li, S K Dickeson, Virginia L Shepherd, Samuel A Santoro, and Mary M Zutter*

Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA
Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, USA

* Corresponding author; email: mary.zutter{at}vanderbilt.edu.

Mast cells play a critical role in innate immunity, allergy, and autoimmune diseases. The receptor/ligand interactions that mediate mast cell activation are poorly defined. The {alpha}2{beta}1 integrin, a receptor for collagens, laminins, decorin, E-cadherin, matrix metalloproteinase-1 (MMP-1), endorepellin, and several viruses, has been implicated in normal developmental, inflammatory, and oncogenic processes. We recently reported that {alpha}2 integrin subunit-deficient mice exhibit markedly diminished neutrophil and IL-6 responses during Listeria monocytogenes-and zymosan-induced peritonitis. Peritoneal mast cells require {alpha}2{beta}1 integrin expression for activation in response to pathogens, yet the ligand and molecular mechanisms by which the {alpha}2{beta}1 integrin induces activation and cytokine secretion remain unknown. We now report that the {alpha}2{beta}1 integrin is a novel receptor for multiple collectins and the C1q complement protein. We demonstrate that the {alpha}2{beta}1 integrin provides a co-stimulatory function required for mast cell activation and cytokine secretion. This finding suggests that the {alpha}2{beta}1 integrin is not only important for innate immunity but may serve as a critical target for the regulation of autoimmune/allergic disorders.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Article in Blood Online:

Mast cells: must they always be different?
Hovav Nechushtan and Ehud Razin
Blood 2006 107: 1-2. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
M. W. Miller, S. Basra, D. W. Kulp, P. C. Billings, S. Choi, M. P. Beavers, O. J. T. McCarty, Z. Zou, M. L. Kahn, J. S. Bennett, et al.
Small-molecule inhibitors of integrin {alpha}2{beta}1 that prevent pathological thrombus formation via an allosteric mechanism
PNAS, January 20, 2009; 106(3): 719 - 724.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
N.-S. Seo, C. Q.-Y. Zeng, J. M. Hyser, B. Utama, S. E. Crawford, K. J. Kim, M. Hook, and M. K. Estes
Inaugural Article: Integrins {alpha}1{beta}1 and {alpha}2{beta}1 are receptors for the rotavirus enterotoxin
PNAS, July 1, 2008; 105(26): 8811 - 8818.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. D. McCall-Culbreath, Z. Li, and M. M. Zutter
Crosstalk between the {alpha}2{beta}1 integrin and c-met/HGF-R regulates innate immunity
Blood, April 1, 2008; 111(7): 3562 - 3570.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
N. O. Gekara, L. Groebe, N. Viegas, and S. Weiss
Listeria monocytogenes Desensitizes Immune Cells to Subsequent Ca2+ Signaling via Listeriolysin O-Induced Depletion of Intracellular Ca2+ Stores
Infect. Immun., February 1, 2008; 76(2): 857 - 862.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
A. P. Senft, T. R. Korfhagen, J. A. Whitsett, and A. M. LeVine
Surfactant protein D regulates the cell surface expression of alveolar macrophage beta2-integrins
Am J Physiol Lung Cell Mol Physiol, February 1, 2007; 292(2): L469 - L475.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020