SEARCH:   Advanced

Blood, 1 May 2006, Vol. 107, No. 9, pp. 3761-3763. Prepublished online as a Blood First Edition Paper on January 10, 2006; DOI 10.1182/blood-2005-06-2235. This Article Full Text (PDF) All Versions of this Article: 2005-06-2235v1 107/9/3761    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kiefel, V. Articles by Greinacher, A. Search for Related Content PubMed PubMed Citation Articles by Kiefel, V. Articles by Greinacher, A. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 3, 2005 Accepted December 28, 2005 Antigen-positive platelet transfusion in neonatal alloimmune thrombocytopenia (NAIT) Volker Kiefel*, Dirk Bassler, Hartmut Kroll, Bosco Paes, Gunter Giers, Juliana Ditomasso, Heidemarie Alber, Monika Berns, Bea Wiebe, Ernst-Markus Quenzel, Jochen Hoch, and Andreas Greinacher Department of Transfusion Medicine, University of Rostock, Rostock, Germany Departments of Pediatrics (Neonatology Division), McMaster University, Hamilton, Ontario, Canada German Red Cross Blood Transfusion Service, Dessau, Germany Institute for Transfusion Medicine and Hemostaseology, University of Dusseldorf, Dusseldorf, Germany Transfusion Medicine, McMaster University, Hamilton, Ontario, Canada Institute for Transfusion Medicine, German Red Cross Blood Transfusion Service, Dresden, Germany Department of Neonatology - Otto Heubner Centre, Charite Campus Virchow, Berlin, Germany Department of Neonatology and Pediatric Intensive Care, Asklepios Clinic, St. Augustin, Germany Department of Transfusion Medicine, Helios Clinic, Schwerin, Germany Institute for Experimental Hematology and Transfusion Medicine, University of Bonn, Bonn, Germany Institute for Immunology and Transfusion Medicine, University of Greifswald, Greifswald, Germany * Corresponding author; email: volker.kiefel{at}med.uni-rostock.de. Neonatal alloimmune thrombocytopenia (NAIT) is a fetomaternal incompatibility, most commonly induced by maternal anti-HPA-1a, IgG alloantibodies against a polymorphic epitope of the glycoprotein IIb/IIIa complex, in approximately 97.5% of Caucasians. Current guidelines recommend transfusion of immunologically compatible platelets to prevent cerebral hemorrhage, the most severe complication in affected newborns. Such platelet concentrates, however, are often not readily available. In a retrospective analysis in German and Canadian centres, twenty-seven newborns with NAIT were identified who received platelets from random donors. Unexpectedly, 24/27 newborns showed an increase above a threshold of 40 x 109 platelets/L, with moderate (n=8) or significant (n=16) platelet count increments ( > 80 x 109 platelets/L). We conclude that transfusion of platelet concentrates from random donors is an appropriate strategy in the management of unexpected, severe NAIT predominantly in first pregnancies, pending the availability of compatible platelets. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: When are platelets just platelets? James B. Bussel Blood 2006 107: 3426-3427. [Full Text] [PDF] This article has been cited by other articles: M. A. Saxonhouse and M. C. Sola-Visner Thrombocytopenia in the Neonatal Intensive Care Unit NeoReviews, September 1, 2009; 10(9): e435 - e445. [Abstract] [Full Text] [PDF] C. Kaplan Neonatal alloimmune thrombocytopenia Haematologica, June 1, 2008; 93(6): 805 - 807. [Full Text] [PDF] D. Allen, S. Verjee, S. Rees, M. F. Murphy, and D. J. Roberts Platelet transfusion in neonatal alloimmune thrombocytopenia Blood, January 1, 2007; 109(1): 388 - 389. [Full Text] [PDF]

	Copyright © 2006 by American Society of Hematology         Online ISSN: 1528-0020