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Blood, 1 January 2006, Vol. 107, No. 1, pp. 52-59. Prepublished online as a Blood First Edition Paper on September 8, 2005; DOI 10.1182/blood-2005-06-2252. This Article Full Text (PDF) All Versions of this Article: 2005-06-2252v1 107/1/52    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hutchings, M. Articles by Specht, L. Search for Related Content PubMed PubMed Citation Articles by Hutchings, M. Articles by Specht, L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 6, 2005 Accepted August 26, 2005 FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin Lymphoma Martin Hutchings*, Annika Loft, Mads T Hansen, Lars M Pedersen, Thora Buhl, Jesper Jurlander, Simon Buus, Susanne Keiding, Francesco D'Amore, Anne-Marie Boesen, Anne K Berthelsen, and Lena Specht Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Copenhagen University Hospital, Copenhagen, Denmark; Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Copenhagen University Hospital, Copenhagen, Denmark Department of Haematology, Copenhagen University Hospital, Copenhagen, Denmark Department of Haematology, University Hospital Herlev, Copenhagen, Denmark PET Center, Aarhus University Hospital, Aarhus, Denmark Department of Haematology, Aarhus University Hospital, Aarhus, Denmark Department of Clinical Physiology and Nuclear Medicine, PET and Cyclotron Unit, Copenhagen University Hospital, Copenhagen, Denmark; Department of Radiotherapy, Copenhagen University Hospital, Copenhagen, Denmark Department of Radiotherapy, Copenhagen University Hospital, Copenhagen, Denmark; Department of Oncology, Copenhagen University Hospital, Copenhagen, Denmark * Corresponding author; email: hutchings{at}dadlnet.dk. Risk-adapted lymphoma treatment requires early and accurate assessment of prognosis. This investigation prospectively assessed the value of positron emission tomography with 2-[18F]fluoro-2-deoxy-D-glucose (FDG-PET) after two cycles of chemotherapy for prediction of progression-free survival (PFS) and overall survival (OS) in HL. 77 consecutive, newly diagnosed patients underwent FDG-PET at staging, after two and four cycles of chemotherapy and after completion of chemotherapy. Median follow-up was 23 months. After two cycles of chemotherapy, 61 patients had negative FDG-PET scans and 16 patients had positive scans. 11 of 16 FDG-PET-positive patients progressed and two died. Three of 61 FDG-PET-negative patients progressed and all were alive at latest follow-up. Survival analyses showed strong associations between early interim FDG-PET and PFS (p < 0.0001) and OS (p < 0.01). For prediction of PFS, Early interim FDG-PET was as accurate after two cycles as later during treatment and superior to CT at all times. In regression analyses, early interim FDG-PET was stronger than established prognostic factors. Other significant prognostic factors were stage and extranodal disease. Early interim FDG-PET is a strong and independent predictor of PFS in HL. A positive early interim FDG-PET is highly predictive of progression in patients with advanced stage or extranodal disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. D. Wolchok, A. Hoos, S. O'Day, J. S. Weber, O. Hamid, C. Lebbe, M. Maio, M. Binder, O. Bohnsack, G. Nichol, et al. Guidelines for the Evaluation of Immune Therapy Activity in Solid Tumors: Immune-Related Response Criteria Clin. Cancer Res., December 1, 2009; 15(23): 7412 - 7420. [Abstract] [Full Text] [PDF] C. Furth, I. G. Steffen, H. Amthauer, J. Ruf, D. 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