|
|
Blood, 15 January 2006, Vol. 107, No. 2, pp. 444-453.
Prepublished online as a Blood First Edition Paper on September 22, 2005; DOI 10.1182/blood-2005-06-2362.
 Previous Article | Next Article 
Submitted June 14, 2005
Accepted September 7, 2005
The Leukotriene B4 Lipid Chemoattractant Receptor BLT1 Defines Antigen-primed T-cells in Humans
Sabina A Islam, Seddon Y Thomas, Christoph Hess, Benjamin D Medoff, Terry K Means, Christian Brander, Craig M Lilly, Andrew M Tager, and Andrew D Luster*
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
* Corresponding author; email: Luster.Andrew{at}mgh.harvard.edu.
We have recently shown that the LTB4-BLT1 pathway is important in early effector T-cell recruitment in mouse models of inflammation. Here we characterize the phenotype and function of human peripheral blood BLT1+ T-cells in health and illustrate their involvement in asthma and acute infection. In healthy individuals, BLT1+ T-cells are a rare peripheral blood T-cell population enriched for the activation markers CD38 and HLA-DR. Compared to BLT1- T-cells, a larger proportion of peripheral blood BLT1+ T-cells express the effector cytokines IFN and IL-4 and inflammatory chemokine receptors, CCR1, -2, -6 and CXCR1. Consequently, in healthy individuals peripheral blood BLT1+ T-cells are a rare antigen-primed T-cell subset with unique phenotypic, migratory and functional properties. BLT1 expression on T-cells is tightly regulated by inflammation and only transiently expressed after naive T-cell activation by dendritic cells. Though rare in the peripheral blood of healthy individuals, BLT1+ T-cells are markedly increased in frequency in the peripheral blood in response to acute EBV infection and moderately increased in the airways of asymptomatic allergic asthmatics. Our studies provide novel insights into the LTB4-BLT1 lipid chemoattractant pathway in human T-cell responses, and how it may link innate and adaptive immunity.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. A. Gubitosi-Klug, R. Talahalli, Y. Du, J. L. Nadler, and T. S. Kern
5-Lipoxygenase, but Not 12/15-Lipoxygenase, Contributes to Degeneration of Retinal Capillaries in a Mouse Model of Diabetic Retinopathy
Diabetes,
May 1, 2008;
57(5):
1387 - 1393.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Liu, H.-E. Claesson, Y. Mahshid, G. Klein, and E. Klein
Leukotriene B4 activates T cells that inhibit B-cell proliferation in EBV-infected cord blood-derived mononuclear cell cultures
Blood,
March 1, 2008;
111(5):
2693 - 2703.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. R. Henderson Jr., E. Y. Chi, J. G. Bollinger, Y.-t. Tien, X. Ye, L. Castelli, Y. P. Rubtsov, A. G. Singer, G. K.S. Chiang, T. Nevalainen, et al.
Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
J. Exp. Med.,
April 16, 2007;
204(4):
865 - 877.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Back, A. Sultan, O. Ovchinnikova, and G. K. Hansson
5-Lipoxygenase-Activating Protein: A Potential Link Between Innate and Adaptive Immunity in Atherosclerosis and Adipose Tissue Inflammation
Circ. Res.,
April 13, 2007;
100(7):
946 - 949.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
