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 Blood, 1 January 2006, Vol. 107, No. 1, pp. 305-308.
Prepublished online as a Blood First Edition Paper on September 20, 2005September 13, 2005; DOI 10.1182/blood-2005-06-2393.

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Submitted June 15, 2005
Accepted August 18, 2005

Bmi-1 is useful as a novel molecular marker for predicting progression of myelodysplastic syndrome and prognosis of the patients

Keichiro Mihara*, Moniruddin Chowdhury, Nanae Nakaju, Sachiko Hidani, Akihiro Ihara, Hideo Hyodo, Shin'ichiro Yasunaga, Yoshihiro Takihara, and Akiro Kimura

Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
Department of Internal Medicine, National Kure Medical Center, Kure, Japan
Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

* Corresponding author; email: kmmihara{at}hiroshima-u.ac.jp.

The International Prognostic Scoring System (IPSS) has been widely used to predict the prognosis of patients with myelodysplastic syndrome (MDS). However, IPSS does not always provide a sufficiently precise evaluation of patients to allow the appropriate choice of clinical interventions. Here we analyzed the expression of Bmi-1, which is required to regulate the self-renewal, in CD34+ cells from 51 Cases with MDS and acute myeloid leukemia preceded by MDS (MDS-AML). Higher positivity rate of Bmi-1 was preferentially seen in refractory anemia with excess blasts (RAEB), RAEB in transformation (RAEB-T) and MDS-AML compared with refractory anemia (RA) and RA with ringed sideroblasts (RARS). IPSS score was positively correlated with the percentage of Bmi-1 expression. RA and RARS patients with a higher percentage of Bmi-1+ cells showed disease progression to RAEB. Here, we propose Bmi-1 as a novel molecular marker to predict the progression and prognosis of MDS.


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