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Blood, 1 February 2006, Vol. 107, No. 3, pp. 885-891. Prepublished online as a Blood First Edition Paper on October 11, 2005; DOI 10.1182/blood-2005-06-2395. This Article Full Text (PDF) All Versions of this Article: 2005-06-2395v1 107/3/885    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Eichhorst, B. F Articles by Hallek, M. Search for Related Content PubMed PubMed Citation Articles by Eichhorst, B. F Articles by Hallek, M. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 15, 2005 Accepted September 13, 2005 Fludarabine plus cyclophosphamide versus fludarabine alone in first line therapy of younger patients with chronic lymphocytic leukemia Barbara F Eichhorst*, Raymonde Busch, Georg Hopfinger, Rita Pasold, Manfred Hensel, Cordelia Steinbrecher, Siegfried Siehl, Ulrich Jaeger, Manuela Bergmann, Stephan Stilgenbauer, Carmen Schweighofer, Clemens M Wendtner, Hartmut Doehner, Guenter Brittinger, Bertold Emmerich, and Michael Hallek Department of Internal Medicine I, University of Cologne, Cologne, Germany Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany Hanusch Hospital, Vienna, Austria Ernst-von-Bergmann Hospital, Potsdam, Germany Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany Hospital Barmherzige Brueder, Regensburg, Germany Clinic for Internal Medicine, Internistische Gemeinschaftspraxis Prof. Hirschmann/Dr. Siehl/Dr. Soling, Kassel, Germany Department of Internal Medicine I, Medical University of Vienna, Vienna, Austria Department of Internal Medicine III, Ludwig-Maximilians-University Munich, Munich, Germany Department of Internal Medicine III, University of Ulm, Ulm, Germany Department of Hematology, University of Duisburg-Essen, Essen, Germany Department of Internal Medicine Innenstadt, Ludwig-Maximilians-University Munich, Munich, Germany * Corresponding author; email: barbara.eichhorst{at}uk-koeln.de. The combination chemotherapy with fludarabine plus cyclophosphamide (FC) was compared to the standard regimen of fludarabine monotherapy in first line treatment of younger patients with chronic lymphocytic leukemia (CLL). Between 1999 and 2003 a total of 375 patients with predominantly advanced CLL younger than 66 years were randomized to receive either fludarabine (25 mg/m2 for 5 days intravenously, repeated every 28 days) or FC combination therapy (fludarabine 30 mg/m2 plus cyclophosphamide 250 mg/m2 both for 3 days intravenously, repeated every 28 days). Both regimens were administered to a maximum of 6 courses. The FC combination chemotherapy resulted in a significantly higher complete remission rate (24%) and overall response rate (94%) compared to fludarabine alone (7% and 83%; P < .001 and P = .001). The FC treatment also resulted in a longer median progression-free survival (48 versus 20 months; P = .001), and a longer treatment-free survival (37 versus 25 months; P < .001). So far, no difference in the median overall survival could be observed. FC caused significantly more thrombocytopenia and leukocytopenia, but did not increase the number of severe infections. In summary first line treatment with FC increases the response rates and the treatment-free interval in young patients with advanced CLL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Treatment and evaluation of CLL: a complicated affair Neil E. Kay Blood 2006 107: 848. [Full Text] [PDF] This article has been cited by other articles: S. O'Brien, J. O. Moore, T. E. Boyd, L. M. Larratt, A. B. Skotnicki, B. Koziner, A. A. Chanan-Khan, J. F. Seymour, J. Gribben, L. M. Itri, et al. 5-Year Survival in Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia in a Randomized, Phase III Trial of Fludarabine Plus Cyclophosphamide With or Without Oblimersen J. Clin. Oncol., November 1, 2009; 27(31): 5208 - 5212. 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