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Blood, 15 June 2006, Vol. 107, No. 12, pp. 4825-4833. Prepublished online as a Blood First Edition Paper on March 7, 2006; DOI 10.1182/blood-2005-06-2463. This Article Full Text (PDF) All Versions of this Article: 2005-06-2463v1 107/12/4825    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pastori, C. Articles by Lopalco, L. Search for Related Content PubMed PubMed Citation Articles by Pastori, C. Articles by Lopalco, L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 23, 2005 Accepted February 9, 2006 Long lasting CCR5 internalization by antibodies in a subset of Long Term Non Progressors: a possible protective effect against disease progression Claudia Pastori, Barbara Weiser, Claudia Barassi, Caterina Uberti-Foppa, Silvia Ghezzi, Renato Longhi, Giliola Calori, Harold Burger, Kimdar Kemal, Guido Poli, Adriano Lazzarin, and Lucia Lopalco* Immunobiology of HIV Unit, Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy Wadsworth Center, NY State Department of Health, Albany, NY, USA Aids Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy Istituto di Biocatalisi e Riconoscimento Molecolare, Milan, Italy Clinic Research Office, San Raffaele Scientific Institute, Milan, Italy Aids Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy; Aids Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy; Wadsworth Center, NY State Department of Health, Albany, NY, USA Immunobiology of HIV Unit, Infectious Diseases Clinic, San Raffaele Scientific Institute, Milan, Italy; Aids Immunopathogenesis Unit, San Raffaele Scientific Institute, Milan, Italy; Wadsworth Center, NY State Department of Health, Albany, NY, USA * Corresponding author; email: lopalco.lucia{at}hsr.it. Exposure to HIV-1 does not necessarily result in infection and progression toward disease, suggesting that the control of viral infection may be achieved. Antibodies (Abs) to CCR5 have been detected in HIV-exposed but uninfected subjects (ESN), thus they could be involved in HIV protection. To assess whether these Abs may also contribute to slow HIV-disease progression, we searched for anti-CCR5 Abs in 497 subjects, including 85 Long Term Non Progressors (LTNP), 70 Progressors, 135 HIV+ HAART treated, and 207 seronegative donors. We found anti-CCR5 Abs in a fraction of LTNP (23.5%), but not in the other populations studied (p< .0001). These Abs recognized a conformed region within the first extramembrane loop of CCR5 and they induced a stable and long lasting down regulation of CCR5 on surface of T lymphocytes, thus blocking HIV entry. In addition, CD4+ lymphocytes from LTNP carrying anti CCR5 Abs are resistance to R5 strains of HIV-1. Follow-up studies showed that the loss of anti-CCR5 Abs, occurred in some subjects, was significantly associated with a progression toward disease, whereas subjects who retained anti CCR5 Abs maintained their LTNP status. Induction of anti-CCR5 Abs could be relevant to vaccine design and therapeutics. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. K. Grant, E. A. Fink, M. Sundstrom, B. E. Torbett, and J. H. Elder Improved health and survival of FIV-infected cats is associated with the presence of autoantibodies to the primary receptor, CD134 PNAS, November 24, 2009; 106(47): 19980 - 19985. [Abstract] [Full Text] [PDF] S. Misumi, M. Masuyama, N. Takamune, D. Nakayama, R. Mitsumata, H. Matsumoto, N. Urata, Y. Takahashi, A. Muneoka, T. Sukamoto, et al. Targeted Delivery of Immunogen to Primate M Cells with Tetragalloyl Lysine Dendrimer J. Immunol., May 15, 2009; 182(10): 6061 - 6070. [Abstract] [Full Text] [PDF] C. Pastori, A. Clivio, L. Diomede, R. Consonni, G. M. S. De Mori, R. Longhi, G. Colombo, and L. Lopalco Two Amino Acid Substitutions within the First External Loop of CCR5 Induce Human Immunodeficiency Virus-Blocking Antibodies in Mice and Chickens J. Virol., April 15, 2008; 82(8): 4125 - 4134. [Abstract] [Full Text] [PDF] J. Catusse, C. M. Parry, D. R. Dewin, and U. A. Gompels Inhibition of HIV-1 infection by viral chemokine U83A via high-affinity CCR5 interactions that block human chemokine-induced leukocyte chemotaxis and receptor internalization Blood, May 1, 2007; 109(9): 3633 - 3639. [Abstract] [Full Text] [PDF] R. Soares, R. Foxall, A. Albuquerque, C. Cortesao, M. Garcia, R. M. M. Victorino, and A. E. Sousa Increased Frequency of Circulating CCR5+ CD4+ T Cells in Human Immunodeficiency Virus Type 2 Infection J. Virol., December 15, 2006; 80(24): 12425 - 12429. [Abstract] [Full Text] [PDF]

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