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 Blood, 15 April 2006, Vol. 107, No. 8, pp. 3265-3270.
Prepublished online as a Blood First Edition Paper on December 27, 2005; DOI 10.1182/blood-2005-06-2480.

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Submitted June 22, 2005
Accepted December 15, 2005

Epithelial specific transcription factor ESE-3 is involved in the development of monocyte derived DC

Silke Appel, Anita Bringmann, Frank Grunebach, Markus M Weck, Jurgen Bauer, and Peter Brossart*

Department of Hematology, Oncology and Immunology, University of Tubingen, Tubingen, Germany
Department of Dermatology, University of Tubingen, Tubingen, Germany

* Corresponding author; email: peter.brossart{at}med.uni-tuebingen.de.

Dendritic cells (DC) are recognized as the most potent antigen presenting cells of the immune system with the unique ability to initiate and maintain primary immune responses. In order to better characterize the functional and phenotypic features of DC, a subtractive cDNA library to identify differentially expressed genes in monocyte derived DC (MDC) was constructed. Using this approach, we found that the epithelial transcription factor ESE-3 that was previously shown to be exclusively expressed in cells of epithelial origin is differentially expressed in MDC. This was further confirmed by RT-PCR and Western blot analyses. The expression of ESE-3 is upregulated upon maturation of MDC and inhibited by treating the cells with IL-10 or IFN-{gamma}. Knockdown experiments using siRNA suggest that ESE-3 plays an important role during MDC development. Our results might help to improve the phenotypic characterization of DC and lead to a better understanding of the cellular mechanisms involved in antigen presentation and T cell stimulation.


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