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Blood, 15 March 2006, Vol. 107, No. 6, pp. 2470-2473. Prepublished online as a Blood First Edition Paper on November 3, 2005; DOI 10.1182/blood-2005-06-2502. This Article Full Text (PDF) All Versions of this Article: 2005-06-2502v1 107/6/2470    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Moldenhauer, G. Articles by Leithauser, F. Search for Related Content PubMed PubMed Citation Articles by Moldenhauer, G. Articles by Leithauser, F. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 23, 2005 Accepted September 25, 2005 AID expression identifies interfollicular large B cells as putative precursors of mature B cell malignancies Gerhard Moldenhauer, Sergey W Popov, Beate Wotschke, Silke Bruderlein, Petra Riedl, Nicolas Fissolo, Reinhold Schirmbeck, Olga Ritz, Peter Moller*, and Frank Leithauser Department of Molecular Immunology, German Cancer Research Center, Heidelberg, Germany Department of Pathology, University of Ulm, Ulm, Germany Department of Medical Microbiology and Immunology, University of Ulm, Ulm, Germany * Corresponding author; email: peter.moeller{at}medizin.uni-ulm.de. Neoplastic transformation of mature B cells can be triggered by class switch recombination of the immunoglobulin gene, which abberantly targets a proto-oncogene and promotes translocation. Class switch recombination is initiated by the B cell-specific protein activation-induced cytidine deaminase (AID). Using immunohistochemistry with a newly generated monoclonal antibody and quantitative RT-PCR on microdissected tissue from lymph node, tonsil and thymus, we demonstrate that AID expression is found in secondary lymphoid organs outside germinal centers and in the thymic medulla at substantial levels. This is accompanied by the presence of circle transcripts, indicating class switch recombination to be active at these sites. The dominant AID-expressing cell population outside germinal centers displays cytomorphological properties corresponding to those that define the recently characterized interfollicular large B cell subset. These findings indicate that interfollicular large B cells and AID-expressing B lymphocytes of the thymic medulla could give rise to mature B cell malignancies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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Gourzi, C. Montano, L. Feigenbaum, P. Wilson, S. Janz, F. N. Papavasiliou, et al. Regulation of AID expression in the immune response J. Exp. Med., May 14, 2007; 204(5): 1145 - 1156. [Abstract] [Full Text] [PDF] P. Bergqvist, E. Gardby, A. Stensson, M. Bemark, and N. Y. Lycke Gut IgA Class Switch Recombination in the Absence of CD40 Does Not Occur in the Lamina Propria and Is Independent of Germinal Centers J. Immunol., December 1, 2006; 177(11): 7772 - 7783. [Abstract] [Full Text] [PDF]

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