SEARCH:   Advanced

Blood, 15 February 2006, Vol. 107, No. 4, pp. 1717-1723. Prepublished online as a Blood First Edition Paper on November 8, 2005; DOI 10.1182/blood-2005-06-2529. This Article Full Text (PDF) All Versions of this Article: 2005-06-2529v1 107/4/1717    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rieger, K. Articles by Uharek, L. Search for Related Content PubMed PubMed Citation Articles by Rieger, K. Articles by Uharek, L. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 27, 2005 Accepted October 9, 2005 Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD Kathrin Rieger*, Christoph Loddenkemper, Jochen Maul, Thomas Fietz, Daniel Wolff, Harald Terpe, Beate Steiner, Erika Berg, Stephan Miehlke, Martin Bornhauser, Thomas Schneider, Martin Zeitz, Harald Stein, Eckhard Thiel, Rainer Duchmann, and Lutz Uharek Medical Clinic III, Hematology, Oncology and Transfusion Medicine, Charite- University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany Consultation and Reference Center for Lymph Node Pathology and Hematopathology- Institute for Pathology, Charite- University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany Medical Clinic II, Gastroenterology, Charite- University Medicine Berlin, Campus Benjamin Franklin, Berlin, Germany Devision of Hematology and Oncology, University of Rostock, Rostock, Germany Department of Pathology, University of Rostock, Rostock, Germany Department of Gastroenterology, University School of Medicine Dresden, Dresden, Germany Department of Hematology, University School of Medicine Dresden, Dresden, Germany * Corresponding author; email: kathrin.rieger{at}charite.de. CD4+CD25+ regulatory T cells (Treg) control immune responses to self- and foreign antigens and play a pivotal role in autoimmune diseases, infectious and non-infectious inflammation and graft rejection. Since recent experimental studies have indicated that Treg were able to ameliorate graft-versus-host-disease (GvHD), we analysed the number of infiltrating Treg in the intestinal mucosa, as one site of GvH-reactivity using immunoenzymatic labeling to enumerate FOXP3+ T cells in 95 intestinal biopsies from 49 allografted patients in comparison to healthy controls and patients with infectious inflammation. While patients with CMV-colitis or diverticulitis showed a concomitant increase of CD8+ effectors and Treg, acute and chronic GvHD were characterized by the complete lack of a counterregulation indicated by a FOXP3+/ CD8+ T cell ratio identical to healthy controls. In contrast, specimens without histological signs of GvHD demonstrated increased numbers of FOXP3+ per CD8+ T cells indicating that the potential for Treg expansion is principally maintained in allografted patients. Our findings provide evidence that GvHD is associated with an insufficient upregulation of Treg in intestinal GvHD lesions. The determination of FOXP3+/ CD8+ ratio can be a helpful tool to discriminate GvHD from infectious inflammation after allogeneic stem cell transplantation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: X. Chen, R. Das, R. Komorowski, A. Beres, M. J. Hessner, M. Mihara, and W. R. Drobyski Blockade of interleukin-6 signaling augments regulatory T-cell reconstitution and attenuates the severity of graft-versus-host disease Blood, July 23, 2009; 114(4): 891 - 900. [Abstract] [Full Text] [PDF] B. Blanco, J. A. Perez-Simon, L. I. Sanchez-Abarca, T. Caballero-Velazquez, S. Gutierrez-Cossio, P. Hernandez-Campo, M. Diez-Campelo, C. Herrero-Sanchez, C. Rodriguez-Serrano, C. Santamaria, et al. Treatment with bortezomib of human CD4+ T cells preserves natural regulatory T cells and allows the emergence of a distinct suppressor T-cell population Haematologica, July 1, 2009; 94(7): 975 - 983. [Abstract] [Full Text] [PDF] A. Maeda, A. Schwarz, A. Bullinger, A. Morita, D. Peritt, and T. Schwarz Experimental Extracorporeal Photopheresis Inhibits the Sensitization and Effector Phases of Contact Hypersensitivity via Two Mechanisms: Generation of IL-10 and Induction of Regulatory T Cells J. Immunol., November 1, 2008; 181(9): 5956 - 5962. [Abstract] [Full Text] [PDF] D. Zhao, C. Zhang, T. Yi, C.-L. Lin, I. Todorov, F. Kandeel, S. Forman, and D. Zeng In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease Blood, September 1, 2008; 112(5): 2129 - 2138. [Abstract] [Full Text] [PDF] K. P. Piper, C. Horlock, S. J. Curnow, J. Arrazi, S. Nicholls, P. Mahendra, C. Craddock, and P. A. H. Moss CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation Blood, December 1, 2007; 110(12): 3827 - 3832. [Abstract] [Full Text] [PDF] X. Chen, S. Vodanovic-Jankovic, B. Johnson, M. Keller, R. Komorowski, and W. R. Drobyski Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease Blood, November 15, 2007; 110(10): 3804 - 3813. [Abstract] [Full Text] [PDF] S. Mielke, K. Rezvani, B. N. Savani, R. Nunes, A. S. M. Yong, J. Schindler, R. Kurlander, V. Ghetie, E. J. Read, S. R. Solomon, et al. Reconstitution of FOXP3+ regulatory T cells (Tregs) after CD25-depleted allotransplantion in elderly patients and association with acute graft-versus-host disease Blood, September 1, 2007; 110(5): 1689 - 1697. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020