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Blood, 15 December 2005, Vol. 106, No. 13, pp. 4377-4380. Prepublished online as a Blood First Edition Paper on August 23, 2005; DOI 10.1182/blood-2005-06-2551. This Article Full Text (PDF) All Versions of this Article: 2005-06-2551v1 106/13/4377    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fraser, C. J Articles by Baker, K S Search for Related Content PubMed PubMed Citation Articles by Fraser, C. J Articles by Baker, K S Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 28, 2005 Accepted August 11, 2005 First report of donor cell derived acute leukemia as a complication of umbilical cord blood transplantation Christopher J Fraser*, Betsy A Hirsch, Vanessa Dayton, Michael H Creer, Joseph P Neglia, John E Wagner, and K S Baker Department of Pediatrics, Division of Hematology, Oncology and Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA Departments of Pathology and Pediatrics, St. Louis University, St. Louis, MO, USA * Corresponding author; email: frase081{at}umn.edu. Donor cell leukemia is a rare complication after allogeneic hematopoietic stem cell transplantation. A twelve month old boy underwent unrelated donor umbilical cord blood transplant (UCBT) for refractory Langerhan's cell histiocytosis. Forty months following transplant he developed acute myeloid leukemia. Cytogenetic and molecular analysis confirmed donor cell origin. The Cord Blood Bank (CBB) contacted the donor's family and established that the child, now seven years old, was healthy. This represents the first reported case of donor cell leukemia following UCBT. This case illustrates that donor cell leukemia is a rare but real event after UCBT as with other stem cell sources and highlights the need for CBBs to maintain linkage data between donors and recipients. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. M. Flynn and D. S. Kaufman Donor cell leukemia: insight into cancer stem cells and the stem cell niche Blood, April 1, 2007; 109(7): 2688 - 2692. [Abstract] [Full Text] [PDF]

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