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Blood, 15 February 2006, Vol. 107, No. 4, pp. 1712-1716. Prepublished online as a Blood First Edition Paper on October 20, 2005; DOI 10.1182/blood-2005-07-2661. This Article Full Text (PDF) All Versions of this Article: 2005-07-2661v1 107/4/1712    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Khoury, H. J Articles by Horowitz, M. M Search for Related Content PubMed PubMed Citation Articles by Khoury, H. J Articles by Horowitz, M. M Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 6, 2005 Accepted September 28, 2005 Impact of posttransplant G-CSF on outcomes of allogeneic hematopoietic stem cell transplantation Hanna J Khoury*, Fausto R Loberiza, Olle Ringden, A J Barrett, Brian J Bolwell, Jean-Yves Cahn, Richard E Champlin, Robert P Gale, Gregory A Hale, Alvaro Urbano-Ispizua, Rodrigo Martino, Philip L McCarthy, Pierre Tiberghien, Leo F Verdonck, and Mary M Horowitz Emory University School of Medicine, Atlanta, Georgia, USA University of Nebraska, Omaha, Nebraska, USA Huddinge University Hospital, Huddinge, Sweden National Heart, Lung and Blood Institute, Bethesda, Maryland, USA Cleveland Clinic Foundation, Cleveland, Ohio, USA Hopital Jean Minjoz, Besancon, France M.D. Anderson Cancer Center, Houston, Texas, USA Center for Advanced Studies in Leukemia, Los Angeles, California, USA St. Jude Children's Research Hospital, Memphis, Tennessee, USA Postgraduate School of Hematology, Barcelona, Spain Hospital Sant Creu I Sant Pau, Barcelona, Spain Roswell Park Cancer Institute, Buffalo, New York, USA Etablissement Francais du Sang, Besancon, France University Hospital Utrecht, Utrecht, The Netherlands Center for International Blood and Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin, USA * Corresponding author; email: hkhoury{at}emory.edu. Granulocyte-colony-stimulating factor (G-CSF) is often administered after hematopoietic cell transplantation (HCT) to accelerate neutrophil recovery, but it is unclear what impact G-CSF has on long-term transplant outcomes. We analyzed within the database of the Center for International Blood and Marrow Transplant Research, the impact of giving posttransplant G-CSF on the outcomes of allogeneic HCT for acute myelogenous leukemia and chronic myelogenous leukemia in 2,719 patients transplanted between 1995 and 2000. These included 1,435 recipients of HLA-identical sibling bone marrow (BM), 609 recipients of HLA-identical peripheral blood stem cells (PBSC), and 675 recipients of unrelated donor BM transplants. Outcomes were compared between patients receiving or not receiving G-CSF within 7 days of HCT according to graft type. Median follow-up was >30 mo (range, 2-87 mo). G-CSF shortened the post-transplant neutropenic period, but did not affect days +30 and +100 treatment-related mortality (TRM). Probabilities of acute and chronic graft-versus-host disease (GVHD), leukemia-free (LFS) and overall survival were similar whether or not G-CSF was given. Multivariate analyses confirmed that giving G-CSF did not affect the risk of GVHD, TRM, LFS, or survival. In conclusion, results of this study found no long-term benefit or disadvantage of giving G-CSF posttransplant to promote hematopoietic recovery. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. S. Miller and B. R. Blazar Response: The role of G-CSF on the risk of graft-versus-host disease after donor lymphocyte infusions Blood, May 15, 2008; 111(10): 5256 - 5257. [Full Text] [PDF] K. L. Andarawewa, A. C. Erickson, W. S. Chou, S. V. Costes, P. Gascard, J. D. Mott, M. J. Bissell, and M. H. Barcellos-Hoff Ionizing Radiation Predisposes Nonmalignant Human Mammary Epithelial Cells to Undergo Transforming Growth Factor {beta} Induced Epithelial to Mesenchymal Transition Cancer Res., September 15, 2007; 67(18): 8662 - 8670. [Abstract] [Full Text] [PDF]

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