SEARCH:   Advanced

Blood, 15 February 2006, Vol. 107, No. 4, pp. 1391-1396. Prepublished online as a Blood First Edition Paper on November 1, 2005; DOI 10.1182/blood-2005-07-2669. This Article Full Text (PDF) All Versions of this Article: 2005-07-2669v1 107/4/1391    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Potti, A. Articles by Ortel, T. L Search for Related Content PubMed PubMed Citation Articles by Potti, A. Articles by Ortel, T. L Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 6, 2005 Accepted September 28, 2005 Gene expression patterns predict phenotypes of immune-mediated thrombosis Anil Potti*, Andrea H Bild, Holly K Dressman, Deborah A Lewis, Joseph R Nevins, and Thomas L Ortel Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, NC, USA; Duke Institute for Genome Sciences and Policy, Durham, NC, USA Duke Institute for Genome Sciences and Policy, Durham, NC, USA; Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA Department of Medicine, Division of Hematology, Duke University Medical Center, Durham, NC, USA; Duke Hemostasis and Thrombosis Center, Durham, NC, USA * Corresponding author; email: anil.potti{at}duke.edu. Antiphospholipid antibody syndrome (APS) is a complex, autoimmune thrombotic disorder with defined clinical phenotypes. Although not all patients with elevated antiphospholipid antibody (aPLA) levels develop complications, the severity of these potential events mandates aggressive and extended, lifelong antithrombotic therapy. 129 patients (57 patients with APS and venous thromboembolism [VTE], 32 patients with VTE without aPLA, 32 patients with aPLA only, and 8 normal healthy patients) were enrolled. RNA from peripheral mononuclear cells was used for DNA microarray analysis. Patterns of gene expression that characterize APS as well as thrombosis in the presence of aPLA were identified by hierarchical clustering and binary regression methods. Gene expression profiles identify and predict individuals with APS from patients with VTE without aPLA. Importantly, similar methods identified expression profiles that accurately predicted those patients with aPLA at 'high risk' for thrombotic events. All profiles were validated in independent cohorts of patients. The ability to predict APS, but more importantly those patients at risk for venous thrombosis, represents a paradigm for a genomic approach that can be applied to other populations of patients with venous thrombosis; providing for more effective clinical management of disease, while also reflecting the possible underlying biologic processes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Genomics and targeting antithrombotic therapy in antiphospholipid syndrome Michael Greaves Blood 2006 107: 1249. [Full Text] [PDF] This article has been cited by other articles: R. C. Becker Advancing Biomarker Science in the 21st Century Circ Cardiovasc Interv, February 1, 2009; 2(1): 4 - 5. [Full Text] [PDF] C Lopez-Pedrera, N Barbarroja, M. Aguirre, L. Torres, F Velasco, and M. Cuadrado Genomics and proteomics: a new approach for assessing thrombotic risk in autoimmune diseases Lupus, October 1, 2008; 17(10): 905 - 916. [Abstract] [PDF] J. Lohrmann and R. C. Becker New Anticoagulants -- The Path from Discovery to Clinical Practice N. Engl. J. Med., June 26, 2008; 358(26): 2827 - 2829. [Full Text] [PDF] R. C. Becker Emerging Paradigms, Platforms, and Unifying Themes in Biomarker Science J. Am. Coll. Cardiol., October 30, 2007; 50(18): 1777 - 1780. [Full Text] [PDF] C. A. Learn, P. E. Fecci, R. J. Schmittling, W. Xie, I. Karikari, D. A. Mitchell, G. E. Archer, Z. Wei, H. Dressman, and J. H. Sampson Profiling of CD4+, CD8+, and CD4+CD25+CD45RO+FoxP3+ T Cells in Patients with Malignant Glioma Reveals Differential Expression of the Immunologic Transcriptome Compared with T Cells from Healthy Volunteers Clin. Cancer Res., December 15, 2006; 12(24): 7306 - 7315. [Abstract] [Full Text] [PDF] K. W. Mahaffey and R. C. Becker The Scientific Community's Quest to Identify Optimal Targets for Anticoagulant Pharmacotherapy Circulation, November 28, 2006; 114(22): 2313 - 2316. [Full Text] [PDF] M Mandel and A Achiron Gene Expression Studies in Systemic Lupus Erythematosus Lupus, July 1, 2006; 15(7): 451 - 456. [Abstract] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020