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Blood, 1 March 2006, Vol. 107, No. 5, pp. 2030-2036.
Prepublished online as a Blood First Edition Paper on November 22, 2005November 29, 2005; DOI 10.1182/blood-2005-07-2696.
 Previous Article | Next Article 
Submitted July 7, 2005
Accepted October 19, 2005
Expression of the DNAM-1 ligands Nectin-2 (CD112) and poliovirus receptor (CD155) on dendritic cells: relevance for Natural Killer/dendritic cells interaction
Daniela Pende*, Roberta Castriconi, Paola Romagnani, Grazia Maria Spaggiari, Stefania Marcenaro, Alessandra Dondero, Elena Lazzeri, Laura Lasagni, Stefania Martini, Paola Rivera, Andrea Capobianco, Lorenzo Moretta, Alessandro Moretta, and Cristina Bottino
Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
DIMES, University of Genova, Genova, Italy; Istituto Giannina Gaslini, Genova, Italy
Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy
Istituto Giannina Gaslini, Genova, Italy; Centro di Eccellenza per la Ricerca Biomedica, University of Genova, Genova, Italy
Istituto Giannina Gaslini, Genova, Italy
DIMES, University of Genova, Genova, Italy
Center for Research, Transfer and High Education DENOthe, University of Florence, Florence, Italy; DOBIG, University of Genova, Genova, Italy
DIMES, University of Genova, Genova, Italy; Istituto Giannina Gaslini, Genova, Italy; Centro di Eccellenza per la Ricerca Biomedica, University of Genova, Genova, Italy
DIMES, University of Genova, Genova, Italy; Centro di Eccellenza per la Ricerca Biomedica, University of Genova, Genova, Italy
* Corresponding author; email: daniela.pende{at}istge.it.
In this study we demonstrate the involvement of DNAM-1 triggering receptor and its ligands PVR and Nectin-2 in Natural Killer (NK) cell-mediated lysis of dendritic cells (DC). The surface expression of both ligands was upregulated in DC as compared to monocytes. It reached maximal densities after DC maturation induced by different stimuli including LPS, Poly I:C, flagellin and CD40L. Both immunohistochemical analysis and confocal microscopy revealed expression of DNAM-1-ligands by DC in lymph nodes in which they were localized in the parafollicular T-cell region and surrounded the high endothelial venules (HEV). Remarkably, in cytolytic assays, DNAM-1 cooperated with NKp30 in the NK-mediated killing of both immature and mature DC and the degree of contribution of DNAM-1 appeared to correlate with the surface densities of its specific ligands PVR and Nectin-2.
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