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Blood, 1 February 2006, Vol. 107, No. 3, pp. 862-869.
Prepublished online as a Blood First Edition Paper on October 18, 2005; DOI 10.1182/blood-2005-07-2702.
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Submitted July 7, 2005
Accepted August 1, 2005
Epstein-barr virus: impact of scientific advance on clinical practice
Hilary Williams and Dorothy H Crawford*
Department of Oncology, Bristol Royal Infirmary, Bristol, United Kingdom
Basic and Clinical Virology Laboratory, Centre for Infectious Diseases, University of Edinburgh, Edinburgh, United Kingdom
* Corresponding author; email: d.crawford{at}ed.ac.uk.
Epstein-Barr virus (EBV) is a tumorigenic herpes virus that infects and persists in B lymphocytes in the majority of humans, generally without causing disease. However, in a few individuals the virus is associated with significant pathology, particularly benign and malignant lymphoproliferations. Recently acquired knowledge on the mechanisms of EBV persistence, immune control of primary and persistent infection, and disease pathogenesis is now being translated into the clinic with novel methods of diagnosis, prevention and treatment contributing to improved patient care. This review concentrates on these recent advances in the field of haematology/oncology.
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