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Blood, 1 March 2006, Vol. 107, No. 5, pp. 2037-2044. Prepublished online as a Blood First Edition Paper on November 17, 2005; DOI 10.1182/blood-2005-07-2760. This Article Full Text (PDF) All Versions of this Article: 2005-07-2760v1 107/5/2037    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cohen, N. Articles by Emilie, D. Search for Related Content PubMed PubMed Citation Articles by Cohen, N. Articles by Emilie, D. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 12, 2005 Accepted October 19, 2005 GILZ expression in human dendritic cells redirects their maturation and prevents antigen-specific T lymphocyte response Nicolas Cohen, Enguerran Mouly, Haifa Hamdi, Marie-Christine Maillot, Marc Pallardy, Veronique Godot, Francis Capel, Axel Balian, Sylvie Naveau, Pierre Galanaud, Francois M Lemoine, and Dominique Emilie* INSERM UMR-S131, Institut Paris-Sud sur les Cytokines, Universite Paris-Sud, Clamart, France CNRS UMR 7087/UPMC, Hopital Pitie-Salpetriere, Assistance Publique-Hopitaux de Paris, Paris, France INSERM UMR-S 461, Faculte de Pharmacie, Universite Paris-Sud, Chatenay-Malabry, France INSERM UMR-S131, Institut Paris-Sud sur les Cytokines, Universite Paris-Sud, Clamart, France; Service d'Hepato-Gastro-Enterologie, Hopital Antoine Beclere, Assistance Publique- Hopitaux de Paris, Institut Paris-Sud sur les Cytokines, Universite Paris-Sud, Clamart, France INSERM UMR-S131, Institut Paris-Sud sur les Cytokines, Universite Paris-Sud, Clamart, France; Service de Microbiologie-Immunologie biologique, Hopital Antoine Beclere, Assistance Publique- Hopitaux de Paris, Institut Paris-Sud sur les Cytokines, Universite Paris-Sud, Clamart, France * Corresponding author; email: emilie{at}ipsc.u-psud.fr. Interleukin (IL)-10 and glucocorticoids (GC) inhibit the ability of antigen-presenting dendritic cells (DC) to stimulate T lymphocytes. We show that induction of GILZ (Glucocorticoid-Induced Leucine Zipper) is involved in this phenomenon. IL-10, dexamethasone (DEX) and transforming growth factor (TGF) stimulate GILZ production in human DC derived from monocytes and from CD34+ cells. GILZ is necessary and sufficient for DEX, IL-10 and TGF modulation of CD80, CD83, CD86, ILT3 and B7-H1 expression by DC and alteration of DC functions. GILZ stimulates the production of IL-10 by immature DC and it prevents the production of inflammatory chemokines by CD40L-activated DC. In contrast, GILZ has no effect on CD40L-mediated inhibition of phagocytosis, indicating that it affects some but not all aspects of DC maturation. GILZ also prevents DC from activating antigen-specific T lymphocyte responses. Administration of GC to patients stimulates GILZ expression in their circulating antigen-presenting cells, and this contributes to the weak lymphocyte responses of GC-treated patients. Thus, regulation of GILZ expression is an important factor determining the decision of DC whether or not to stimulate T lymphocytes, and IL-10, GC and TGF share this mechanism for influencing DC functions and the balance between immune response and tolerance. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: E. Ayroldi and C. Riccardi Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action FASEB J, November 1, 2009; 23(11): 3649 - 3658. [Abstract] [Full Text] [PDF] S. Chamorro, J. J. Garcia-Vallejo, W. W. J. Unger, R. J. Fernandes, S. C. M. Bruijns, S. Laban, B. O. Roep, B. A. 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