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 Blood, 1 April 2006, Vol. 107, No. 7, pp. 2673-2679.
Prepublished online as a Blood First Edition Paper on November 29, 2005; DOI 10.1182/blood-2005-07-2797.

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Submitted July 14, 2005
Accepted November 9, 2005

Expression of rearranged TCR{gamma} genes in natural killer cells suggests a minor thymus-dependent pathway of lineage commitment

Linnea L Veinotte, Chelsea P Greenwood, Nastaran Mohammadi, Christine A Parachoniak, and Fumio Takei*

Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada
Terry Fox Laboratory, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada

* Corresponding author; email: ftakei{at}bccrc.ca.

NK cells are thought to develop from common lymphoid progenitors in the bone marrow. However, immature thymocytes also retain NK potential. Currently, the contribution of the thymus-dependent pathway in normal steady-state NK cell development is unknown. Here, we show that TCR{gamma} genes are rearranged in approximately 5% of neonatal and 1% of adult mouse splenic NK cells and similar levels are detected in NK cells from TCR{beta},{delta}-double knockout mice, excluding the possibility of T cell contamination. NK cell TCR{gamma} gene rearrangement is thymus-dependent as this rearrangement is undetectable in nude mouse NK cells. These results change the current view of NK cell development and show that a subset of NK cells develop from immature thymocytes that have rearranged TCR{gamma} genes.


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