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Blood, 15 April 2006, Vol. 107, No. 8, pp. 3313-3320. Prepublished online as a Blood First Edition Paper on December 20, 2005; DOI 10.1182/blood-2005-07-2823. This Article Full Text (PDF) Supplemental Figure All Versions of this Article: 2005-07-2823v1 107/8/3313    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Talora, C. Articles by Screpanti, I. Search for Related Content PubMed PubMed Citation Articles by Talora, C. Articles by Screpanti, I. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 15, 2005 Accepted December 4, 2005 Cross-talk among Notch3, pre-TCR and Tal-1 in T-cell development and leukemogenesis Claudio Talora, Samantha Cialfi, Christian Oliviero, Rocco Palermo, Monica Pascucci, Luigi Frati, Alessandra Vacca, Alberto Gulino, and Isabella Screpanti* Department of Experimental Medicine and Pathology, University "La Sapienza", Roma, Italy Department of Experimental Medicine, University of L'Aquila, L'Aquila, Italy Department of Experimental Medicine and Pathology, University "La Sapienza", Roma, Italy; Neuromed Institute, Pozzilli, Italy Department of Experimental Medicine and Pathology, University "La Sapienza", Roma, Italy; Istituto Pasteur-Fondazione Cenci Bolognetti, University 'La Sapienza', Roma, Italy * Corresponding author; email: isabella.screpanti{at}uniroma1.it. Integrated pathways are believed to determine hematopoietic cell fate and/or neoplastic transformation. Notch signaling has been shown to regulate T cell differentiation and leukemogenesis. However, specific target genes and molecular partners are not fully elucidated. We show that Notch3 activation sustains aberrant SCL/Tal1 overexpression and phosphorylation in mature thymocytes. Furthermore, we define the role of SCL/Tal1 as a component of an activator complex, including phosphorylated Tal1 and Sp1, that specifically enhances cyclin D1 expression and demonstrate that Tal1/Sp1 specifically co-occupy the D1 promoter in vivo, only in the presence of pre-TCR. We therefore conclude not only that cyclin D1 is a target of the Tal1/Sp1 complex, but also that Notch3 dependent activation of pre-TCR/ERK signaling regulates SCL/Tal1 function. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. T. Park, I.-M. Shih, and T.-L. Wang Identification of Pbx1, a Potential Oncogene, as a Notch3 Target Gene in Ovarian Cancer Cancer Res., November 1, 2008; 68(21): 8852 - 8860. [Abstract] [Full Text] [PDF] M. Xu, Q. Yu, R. Subrahmanyam, M. J. Difilippantonio, T. Ried, and J. M. Sen {beta}-Catenin Expression Results in p53-Independent DNA Damage and Oncogene-Induced Senescence in Prelymphomagenic Thymocytes In Vivo Mol. Cell. Biol., March 1, 2008; 28(5): 1713 - 1723. [Abstract] [Full Text] [PDF] J. R. Gothert, R. L. Brake, M. Smeets, U. Duhrsen, C. G. Begley, and D. J. Izon NOTCH1 pathway activation is an early hallmark of SCL T leukemogenesis Blood, November 15, 2007; 110(10): 3753 - 3762. [Abstract] [Full Text] [PDF] K.-A. Kim, J.-H. Kim, Y. Wang, and H. S. Sul Pref-1 (Preadipocyte Factor 1) Activates the MEK/Extracellular Signal-Regulated Kinase Pathway To Inhibit Adipocyte Differentiation Mol. Cell. Biol., March 15, 2007; 27(6): 2294 - 2308. [Abstract] [Full Text] [PDF] P.-Y. Chang, K. Draheim, M. A. Kelliher, and S. Miyamoto NFKB1 Is a Direct Target of the TAL1 Oncoprotein in Human T Leukemia Cells. Cancer Res., June 15, 2006; 66(12): 6008 - 6013. [Abstract] [Full Text] [PDF]

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