SEARCH:   Advanced

Blood, 15 February 2006, Vol. 107, No. 4, pp. 1427-1433. Prepublished online as a Blood First Edition Paper on October 18, 2005; DOI 10.1182/blood-2005-07-2907. This Article Full Text (PDF) All Versions of this Article: 2005-07-2907v1 107/4/1427    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Jansen, C. A Articles by Miedema, F. Search for Related Content PubMed PubMed Citation Articles by Jansen, C. A Articles by Miedema, F. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 20, 2005 Accepted September 29, 2005 Prognostic value of HIV-1 Gag-specific CD4+ T-cell responses for progression to AIDS analysed in a prospective cohort study Christine A Jansen, Iris M De Cuyper, Berend Hooibrink, Akke K van der Bij, Debbie van Baarle, and Frank Miedema* Department of Clinical Viro-Immunology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Immunology, University Medical Center, Utrecht, The Netherlands Department of Clinical Viro-Immunology, Sanquin Research and Landsteiner Laboratory of the Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Department of HIV&STI Research, Cluster of Infectious Diseases, Municipal Health Service, University of Amsterdam, Amsterdam, The Netherlands * Corresponding author; email: f.miedema{at}umcutrecht.nl. The causal relationship between HIV-specific CD4+ T-cell responses and viral control and the impact of these responses on the natural history of HIV infection is unclear. In a detailed longitudinal study, functional HIV-1 Gag-specific CD4+ T cells were analysed in long-term asymptomatic individuals (LTA, n=6) and progressors to AIDS (n=7) with a median follow-up of respectively 118 and 57 months. Next, HIV-specific CD4+ T-helper cell responses were measured in a prospective cohort study among 96 HIV seroconverters and were related to clinical endpoints using Cox-proportional hazard analysis. In the detailed study, no difference for HIV-specific helper cell responses between LTA and progressors was observed early in infection, but Gag-specific CD4+ T cells producing IL-2 or IFN were lost in progressors late in infection. Multivariate proportional hazard analyses in the prospective cohort study showed that HIV-specific IL-2+, IFN+ or IL-2+IFN+ CD4+ T cells early after seroconversion had no prognostic value for the rate of progression to AIDS. Our results are compatible with viral load determining the nature and magnitude of HIV-specific CD4+ T-cell responses, rather than HIV-specific CD4+ T-cell responses controlling HIV plasma viral load. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Are HIV-specific CD4+ T cells useless? Guido Vanham Blood 2006 107: 1253. [Full Text] [PDF] This article has been cited by other articles: W. A. Burgers, C. Riou, M. Mlotshwa, P. Maenetje, D. de Assis Rosa, J. Brenchley, K. Mlisana, D. C. Douek, R. Koup, M. Roederer, et al. Association of HIV-Specific and Total CD8+ T Memory Phenotypes in Subtype C HIV-1 Infection with Viral Set Point J. Immunol., April 15, 2009; 182(8): 4751 - 4761. [Abstract] [Full Text] [PDF] S. J. Potter, C. Lacabaratz, O. Lambotte, S. Perez-Patrigeon, B. Vingert, M. Sinet, J.-H. Colle, A. Urrutia, D. Scott-Algara, F. Boufassa, et al. Preserved Central Memory and Activated Effector Memory CD4+ T-Cell Subsets in Human Immunodeficiency Virus Controllers: an ANRS EP36 Study J. Virol., December 15, 2007; 81(24): 13904 - 13915. [Abstract] [Full Text] [PDF] S. K. Choudhary, N. Vrisekoop, C. A. Jansen, S. A. Otto, H. Schuitemaker, F. Miedema, and D. Camerini Low Immune Activation despite High Levels of Pathogenic Human Immunodeficiency Virus Type 1 Results in Long-Term Asymptomatic Disease J. Virol., August 15, 2007; 81(16): 8838 - 8842. [Abstract] [Full Text] [PDF] L. Dorrell, H. Yang, B. Ondondo, T. Dong, K. di Gleria, A. Suttill, C. Conlon, D. Brown, P. Williams, P. Bowness, et al. Expansion and Diversification of Virus-Specific T Cells following Immunization of Human Immunodeficiency Virus Type 1 (HIV-1)-Infected Individuals with a Recombinant Modified Vaccinia Virus Ankara/HIV-1 Gag Vaccine. J. Virol., May 1, 2006; 80(10): 4705 - 4716. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020