SEARCH:   Advanced

Blood, 15 March 2006, Vol. 107, No. 6, pp. 2392-2399. Prepublished online as a Blood First Edition Paper on November 17, 2005; DOI 10.1182/blood-2005-07-2913. This Article Full Text (PDF) All Versions of this Article: 2005-07-2913v1 107/6/2392    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Frasca, L. Articles by Ausiello, C. M Search for Related Content PubMed PubMed Citation Articles by Frasca, L. Articles by Ausiello, C. M Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 20, 2005 Accepted October 27, 2005 CD38 orchestrates migration, survival and th1-immune response of human mature dendritic cells Loredana Frasca, Giorgio Fedele, Silvia Deaglio, Cristina Capuano, Raffaella Palazzo, Tiziana Vaisitti, Fabio Malavasi, and Clara M Ausiello* Department of Infectious, Parasitic and Immune-mediated Diseases, Istituto Superiore di Sanita, Rome, Italy Department of Genetics, Biology and Biochemistry and Ceppellini Institute for Human Genetics, University of Torino Medical School, Turin, Italy * Corresponding author; email: ausiello{at}iss.it. CD38, an ectoenzyme and a signaling receptor, is a novel marker of human mature monocyte-derived dendritic cells (MDDC). The working hypothesis is that CD38 is not only a marker, but contributes to functions specifically gained by MDDC with maturation. This was tested by assessing the role(s) of CD38 after signaling with agonistic anti-CD38 monoclonal antibodies, or blocking the interactions taking place between CD38 and CD31, its counter-receptor. The results indicate that i) CD38 engagement in MDDC ensures efficient chemotaxis and trans-endothelial migration driven by CC chemokine ligand (CCL) 21; ii) CD38 is laterally associated with the CCL21-specific CC chemokine receptor 7 and with CD83 and CD11b, and iii) it localizes in membrane lipid domains; further, CD38 signaling contributes to support iv) longevity of LPS-matured MDDC after growth factor withdrawal, and v) IFN-production by co-cultured T lymphocytes, thus affecting Th1 polarization. These data suggest that the localization of CD38 in lipid rafts and its multiple interactions with signaling receptors rule innate and adaptive immune responses by tuning DC migration, survival and Th1-polarization ability. These findings lay out the basis to assess the functional role(s) of human CD38 in infections, autoimmune diseases and neoplastic disorders. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Nasso, G. Fedele, F. Spensieri, R. Palazzo, P. Costantino, R. Rappuoli, and C. M. Ausiello Genetically Detoxified Pertussis Toxin Induces Th1/Th17 Immune Response through MAPKs and IL-10-Dependent Mechanisms J. Immunol., August 1, 2009; 183(3): 1892 - 1899. [Abstract] [Full Text] [PDF] S. Alzabin, N. Bhardwaj, F. Kiefer, S. Sawasdikosol, and S. Burakoff Hematopoietic Progenitor Kinase 1 Is a Negative Regulator of Dendritic Cell Activation J. Immunol., May 15, 2009; 182(10): 6187 - 6194. [Abstract] [Full Text] [PDF] S. Munir, C. Le Nouen, C. Luongo, U. J. Buchholz, P. L. Collins, and A. Bukreyev Nonstructural Proteins 1 and 2 of Respiratory Syncytial Virus Suppress Maturation of Human Dendritic Cells J. Virol., September 1, 2008; 82(17): 8780 - 8796. [Abstract] [Full Text] [PDF] F. Malavasi, S. Deaglio, A. Funaro, E. Ferrero, A. L. Horenstein, E. Ortolan, T. Vaisitti, and S. Aydin Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology Physiol Rev, July 1, 2008; 88(3): 841 - 886. [Abstract] [Full Text] [PDF] P. Munoz, M. Mittelbrunn, H. de la Fuente, M. Perez-Martinez, A. Garcia-Perez, A. Ariza-Veguillas, F. Malavasi, M. Zubiaur, F. Sanchez-Madrid, and J. Sancho Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse Blood, April 1, 2008; 111(7): 3653 - 3664. [Abstract] [Full Text] [PDF] L. Frasca, M. Nasso, F. Spensieri, G. Fedele, R. Palazzo, F. Malavasi, and C. M. Ausiello IFN-{gamma} Arms Human Dendritic Cells to Perform Multiple Effector Functions J. Immunol., February 1, 2008; 180(3): 1471 - 1481. [Abstract] [Full Text] [PDF] A. G. P. Guedes, J. A. Jude, J. Paulin, H. Kita, F. E. Lund, and M. S. Kannan Role of CD38 in TNF-{alpha}-induced airway hyperresponsiveness Am J Physiol Lung Cell Mol Physiol, February 1, 2008; 294(2): L290 - L299. [Abstract] [Full Text] [PDF] S. Partida-Sanchez, A. Gasser, R. Fliegert, C. C. Siebrands, W. Dammermann, G. Shi, B. J. Mousseau, A. Sumoza-Toledo, H. Bhagat, T. F. Walseth, et al. Chemotaxis of Mouse Bone Marrow Neutrophils and Dendritic Cells Is Controlled by ADP-Ribose, the Major Product Generated by the CD38 Enzyme Reaction J. Immunol., December 1, 2007; 179(11): 7827 - 7839. [Abstract] [Full Text] [PDF] R. N. Damle, S. Temburni, C. Calissano, S. Yancopoulos, T. Banapour, C. Sison, S. L. Allen, K. R. Rai, and N. Chiorazzi CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells Blood, November 1, 2007; 110(9): 3352 - 3359. [Abstract] [Full Text] [PDF] N. Gallay, L. Anani, A. Lopez, P. Colombat, C. Binet, J. Domenech, B. B. Weksler, F. Malavasi, and O. Herault The Role of Platelet/Endothelial Cell Adhesion Molecule 1 (CD31) and CD38 Antigens in Marrow Microenvironmental Retention of Acute Myelogenous Leukemia Cells Cancer Res., September 15, 2007; 67(18): 8624 - 8632. [Abstract] [Full Text] [PDF] P. Hartiala, J. Hytonen, J. Pelkonen, K. Kimppa, A. West, M. A. Penttinen, J. Suhonen, R. Lahesmaa, and M. K. Viljanen Transcriptional response of human dendritic cells to Borrelia garinii--defective CD38 and CCR7 expression detected J. Leukoc. Biol., July 1, 2007; 82(1): 33 - 43. [Abstract] [Full Text] [PDF] S. Deaglio, T. Vaisitti, R. Billington, L. Bergui, P. Omede', A. A. Genazzani, and F. Malavasi CD38/CD19: a lipid raft-dependent signaling complex in human B cells Blood, June 15, 2007; 109(12): 5390 - 5398. [Abstract] [Full Text] [PDF] S. Deaglio, T. Vaisitti, S. Aydin, E. Ferrero, and F. Malavasi In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia Blood, August 15, 2006; 108(4): 1135 - 1144. [Abstract] [Full Text] [PDF] F. Spensieri, G. Fedele, C. Fazio, M. Nasso, P. Stefanelli, P. Mastrantonio, and C. M. Ausiello Bordetella pertussis Inhibition of Interleukin-12 (IL-12) p70 in Human Monocyte-Derived Dendritic Cells Blocks IL-12 p35 through Adenylate Cyclase Toxin-Dependent Cyclic AMP Induction. Infect. Immun., May 1, 2006; 74(5): 2831 - 2838. [Abstract] [Full Text] [PDF]

	Copyright © 2005 by American Society of Hematology         Online ISSN: 1528-0020