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Blood, 1 April 2006, Vol. 107, No. 7, pp. 2613-2618. Prepublished online as a Blood First Edition Paper on November 29, 2005; DOI 10.1182/blood-2005-07-2965. This Article Full Text (PDF) Supplemental Table and Figure All Versions of this Article: 2005-07-2965v1 107/7/2613    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Piqueras, B. Articles by Banchereau, J. Search for Related Content PubMed PubMed Citation Articles by Piqueras, B. Articles by Banchereau, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 25, 2005 Accepted November 10, 2005 Upon viral exposure myeloid and plasmacytoid dendritic cells produce three waves of distinct chemokines to recruit immune effectors Bernard Piqueras, John Connolly, Heidi Freitas, Anna K Palucka, and Jacques Banchereau* Baylor NIAID Cooperative Center for Translational Research on Human Immunology and Biodefense, Dallas, TX, USA; Baylor Institute for Immunology Research, Dallas, TX, USA * Corresponding author; email: jacquesb{at}baylorhealth.edu. Host response to viral infection involves distinct effectors of the innate and adaptive immunity, whose mobilization needs to be coordinated to insure protection. Here we show that Influenza virus triggers in human blood dendritic cell (DC) subsets, i.e., plasmacytoid and myeloid DCs, a coordinated chemokine (CK) secretion program with three successive waves. The first one, occurring at early time points (2-4 hours), includes CKs potentially attracting effector cells like neutrophils, cytotoxic T and NK cells (CXCL16, CXCL1, CXCL2, and CXCL3). The second one occurs within 8 to 12 hours and includes CKs attracting effector memory T cells (CXCL8, CCL3, CCL4, CCL5, CXCL9, CXCL10, and CXCL11). The third wave, which occurs after 24-48 hours, when DCs have reached the lymphoid organs, includes CCL19, CCL22 and CXCL13, which attract naive T and B lymphocytes. Thus, human blood DC subsets carry a common program of CK production, which allow for a coordinated attraction of the different immune effectors in response to viral infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Michaelis, J. Geiler, D. Klassert, H. W. Doerr, and J. Cinatl Jr Infection of Human Retinal Pigment Epithelial Cells with Influenza A Viruses Invest. Ophthalmol. Vis. 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