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Blood, 1 April 2006, Vol. 107, No. 7, pp. 2605-2612. Prepublished online as a Blood First Edition Paper on December 6, 2005; DOI 10.1182/blood-2005-07-2991. This Article Full Text (PDF) All Versions of this Article: 2005-07-2991v1 107/7/2605    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lensch, M W Articles by Daley, G. Q Search for Related Content PubMed PubMed Citation Articles by Lensch, M W Articles by Daley, G. Q Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 26, 2005 Accepted November 25, 2005 Scientific and clinical opportunities for modeling blood disorders with embryonic stem cells M W Lensch and George Q Daley* Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA; Division of Hematology/Oncology, Children's Hospital Boston, Boston, Massachusetts, USA; Harvard Stem Cell Institute, Cambridge, Massachusetts, USA * Corresponding author; email: George.Daley{at}childrens.harvard.edu. Our considerable wealth of data concerning hematological processes has come despite difficulties working with stem and progenitor cells in vitro and their propensity to differentiate. Key methodologies that have sought to overcome such limitations include transgenic/knock-out animals and in vitro studies using murine embryonic stem cells, as both permit investigation of the formation of hematopoietic tissue from non-hematopoietic precursors. Although there have been many successful studies in model animals for understanding hematopoietic cell development, differences between lower vertebrates and humans have left gaps in our understanding. Clearly, human-specific strategies to study the onset of hematopoiesis, particularly the earliest events leading to the specification of both normal and abnormal hematopoietic tissue, could bring an investigational renaissance. The recent availability of human embryonic stem (hES) cells suggests that such a system is now at hand. This review highlights the potential of hES cells to model human hematological processes in vitro with an emphasis on disease targets. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. W. Lensch Cellular reprogramming and pluripotency induction Br. Med. Bull., June 1, 2009; 90(1): 19 - 35. [Abstract] [Full Text] [PDF]

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