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Blood, 1 February 2006, Vol. 107, No. 3, pp. 1220-1226. Prepublished online as a Blood First Edition Paper on October 18, 2005; DOI 10.1182/blood-2005-08-3121. This Article Full Text (PDF) All Versions of this Article: 2005-08-3121v1 107/3/1220    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Shaw, B. E Articles by Madrigal, J A Search for Related Content PubMed PubMed Citation Articles by Shaw, B. E Articles by Madrigal, J A Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 3, 2005 Accepted September 23, 2005 HLA-DPB1 matching status has significant implications for recipients of Unrelated Donor Stem Cell Transplants Bronwen E Shaw*, Steven G Marsh, Neema P Mayor, Nigel H Russell, and J A Madrigal Anthony Nolan Research Institute, London, United Kingdom; Nottingham City Hospital, Nottingham, United Kingdom Anthony Nolan Research Institute, London, United Kingdom; Royal Free and University College London Medical School, London, United Kingdom Anthony Nolan Research Institute, London, United Kingdom Nottingham City Hospital, Nottingham, United Kingdom * Corresponding author; email: bshaw{at}doctors.org.uk. Studies in Unrelated Donor (UD) Haematopoietic Stem Cell Transplants (HSCT), show an impact of the matching status of HLA-DPB1 on complications. We analysed 423 UD-HSCT pairs. Most protocols included T cell depletion (TCD). All pairs had high resolution tissue typing performed for six HLA loci. 282 pairs were matched at 10/10 alleles (29% were DPB1 matched). In 141 HLA mismatched pairs, 28% were matched for DPB1. In the10/10 matched pairs (N=282), the three year probability of relapse was 61%. This was significantly higher in DPB1 matched pairs (74%) as compared to DPB1 mismatched pairs (56%) (log rank, p=0.001). This finding persisted in multivariate analysis. In the group overall (N=423), relapse was also significantly increased if DPB1 was matched (log rank; p=0.0001). These results were similar in CML (p=0.0009) and ALL (p=0.013). In ALL DPB1 matched pairs had a significantly worse overall survival (log rank; p=0.025). Thus, in recipients of TCD UD-HSCT, a match for DPB1 is associated with a significantly increased risk of disease relapse, irrespective of the matching status for the other HLA molecules. It is possible that this effect is especially apparent following TCD transplants and invites speculation about the function of DPB1 within the immune system. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Fernandez-Vina, S. Parmar, R. Champlin, and M. de Lima Response: MHC class I chain-related gene A (MICA) in unrelated donor transplantation Blood, November 19, 2009; 114(21): 4754 - 4755. [Full Text] [PDF] R. Crocchiolo, E. Zino, L. Vago, R. Oneto, B. Bruno, S. Pollichieni, N. Sacchi, M. P. Sormani, J. Marcon, T. Lamparelli, et al. Nonpermissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation Blood, August 13, 2009; 114(7): 1437 - 1444. [Abstract] [Full Text] [PDF] B. E. Shaw, T. A. Gooley, M. Malkki, J. A. Madrigal, A. B. Begovich, M. M. Horowitz, A. Gratwohl, O. Ringden, S. G. E. Marsh, and E. W. Petersdorf The importance of HLA-DPB1 in unrelated donor hematopoietic cell transplantation Blood, December 15, 2007; 110(13): 4560 - 4566. [Abstract] [Full Text] [PDF] S. J. Lee, J. Klein, M. Haagenson, L. A. Baxter-Lowe, D. L. Confer, M. Eapen, M. Fernandez-Vina, N. Flomenberg, M. Horowitz, C. K. Hurley, et al. High-resolution donor-recipient HLA matching contributes to the success of unrelated donor marrow transplantation Blood, December 15, 2007; 110(13): 4576 - 4583. [Abstract] [Full Text] [PDF] N. P. Mayor, B. E. Shaw, D. A. Hughes, H. Maldonado-Torres, J. A. Madrigal, S. Keshav, and S. G.E. Marsh Single Nucleotide Polymorphisms in the NOD2/CARD15 Gene Are Associated With an Increased Risk of Relapse and Death for Patients With Acute Leukemia After Hematopoietic Stem-Cell Transplantation With Unrelated Donors J. Clin. Oncol., September 20, 2007; 25(27): 4262 - 4269. [Abstract] [Full Text] [PDF] I. Yakoub-Agha, F. Mesnil, M. Kuentz, J. M. Boiron, N. Ifrah, N. Milpied, S. Chehata, H. Esperou, J.-P. Vernant, M. Michallet, et al. Allogeneic Marrow Stem-Cell Transplantation From Human Leukocyte Antigen-Identical Siblings Versus Human Leukocyte Antigen-Allelic-Matched Unrelated Donors (10/10) in Patients With Standard-Risk Hematologic Malignancy: A Prospective Study From the French Society of Bone Marrow Transplantation and Cell Therapy J. Clin. Oncol., December 20, 2006; 24(36): 5695 - 5702. [Abstract] [Full Text] [PDF]

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