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Blood, 1 April 2006, Vol. 107, No. 7, pp. 2774-2776. Prepublished online as a Blood First Edition Paper on December 8, 2005; DOI 10.1182/blood-2005-08-3210. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: 2005-08-3210v1 107/7/2774    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Duda, D. G Articles by Jain, R. K Search for Related Content PubMed PubMed Citation Articles by Duda, D. G Articles by Jain, R. K Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 10, 2005 Accepted November 25, 2005 Evidence for bone marrow-derived endothelial cells incorporation into perfused blood vessels in tumors Dan G Duda, Kenneth S Cohen, Sergey V Kozin, Jean Y Perentes, Dai Fukumura, David T Scadden, and Rakesh K Jain* Department of Radiation Oncology, E.L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA, USA Department of Radiation Oncology, E.L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Boston, MA, USA; Department of Thoracic Surgery, University Hospital of Lausanne, Lausanne, Switzerland * Corresponding author; email: jain{at}steele.mgh.harvard.edu. Recent studies have demonstrated that the cellular contribution of the bone marrow to tumor neovascularization is highly complex. In this context, the extent to which bone marrow-derived cells incorporate as bona fide endothelial (non-hematopoietic) cells into perfused tumor vessels, or any new vessels formed postnatally (vasculogenesis), is unclear. To this end, we developed models to characterize local vessel-derived and bone marrow-derived endothelial cells (BMD-ECs). Then, we characterized the BMD-ECs based on a set of endothelial markers and morphology. Finally, we quantified their contribution to perfused blood vessels in tumors using transplanted as well as spontaneous primary and metastatic tumor models. We demonstrate that BMD-ECs incorporate in perfused tumor vessels, and that this contribution varies with organ site and mouse strain. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. J. Madlambayan, J. M. Butler, K. Hosaka, M. Jorgensen, D. Fu, S. M. Guthrie, A. K. Shenoy, A. Brank, K. J. Russell, J. Otero, et al. Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger Blood, November 5, 2009; 114(19): 4310 - 4319. [Abstract] [Full Text] [PDF] C. Folkins, Y. Shaked, S. Man, T. Tang, C. R. Lee, Z. Zhu, R. M. Hoffman, and R. S. Kerbel Glioma Tumor Stem-Like Cells Promote Tumor Angiogenesis and Vasculogenesis via Vascular Endothelial Growth Factor and Stromal-Derived Factor 1 Cancer Res., September 15, 2009; 69(18): 7243 - 7251. [Abstract] [Full Text] [PDF] M. Taylor, J. Rossler, B. Geoerger, A. Laplanche, O. Hartmann, G. Vassal, and F. Farace High Levels of Circulating VEGFR2+ Bone Marrow-Derived Progenitor Cells Correlate with Metastatic Disease in Patients with Pediatric Solid Malignancies Clin. Cancer Res., July 15, 2009; 15(14): 4561 - 4571. [Abstract] [Full Text] [PDF] A. S. Chi, A. G. Sorensen, R. K. Jain, and T. T. Batchelor Angiogenesis as a Therapeutic Target in Malignant Gliomas Oncologist, June 1, 2009; 14(6): 621 - 636. [Abstract] [Full Text] [PDF] J. Ruan, K. Hajjar, S. Rafii, and J. P. Leonard Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma Ann. Onc., March 1, 2009; 20(3): 413 - 424. [Abstract] [Full Text] [PDF] R. G. Bagley, C. Rouleau, T. St. Martin, P. Boutin, W. Weber, M. Ruzek, N. Honma, M. Nacht, S. Shankara, S. Kataoka, et al. Human endothelial precursor cells express tumor endothelial marker 1/endosialin/CD248 Mol. Cancer Ther., August 1, 2008; 7(8): 2536 - 2546. [Abstract] [Full Text] [PDF] K. Reddy, Z. Zhou, K. Schadler, S.-F. Jia, and E. S. Kleinerman Bone Marrow Subsets Differentiate into Endothelial Cells and Pericytes Contributing to Ewing's Tumor Vessels Mol. Cancer Res., June 1, 2008; 6(6): 929 - 936. [Abstract] [Full Text] [PDF] N. Tang, G. Du, N. Wang, C. Liu, H. Hang, and W. Liang Improving Penetration in Tumors With Nanoassemblies of Phospholipids and Doxorubicin J Natl Cancer Inst, July 4, 2007; 99(13): 1004 - 1015. [Abstract] [Full Text] [PDF] D. J. Nolan, A. Ciarrocchi, A. S. Mellick, J. S. Jaggi, K. Bambino, S. Gupta, E. Heikamp, M. R. McDevitt, D. A. Scheinberg, R. Benezra, et al. Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization Genes & Dev., June 15, 2007; 21(12): 1546 - 1558. [Abstract] [Full Text] [PDF] A. Aicher, M. Rentsch, K.-i. Sasaki, J. W. Ellwart, F. Fandrich, R. Siebert, J. P. Cooke, S. Dimmeler, and C. Heeschen Nonbone Marrow-Derived Circulating Progenitor Cells Contribute to Postnatal Neovascularization Following Tissue Ischemia Circ. Res., March 2, 2007; 100(4): 581 - 589. [Abstract] [Full Text] [PDF] G. C. Schatteman, M. Dunnwald, and C. Jiao Biology of bone marrow-derived endothelial cell precursors Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H1 - H18. [Abstract] [Full Text] [PDF]

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